Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

被引：0
|
作者：
Khaled A. M. Abouzid
Nadia A. Khalil
Eman M. Ahmed
机构：
[1] Ain Shams University,Pharmaceutical Chemistry Department, Faculty of Pharmacy
[2] Cairo University,Organic Chemistry Department, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Breast cancer; Anti-proliferative activity; Phthalazine; Phthalazinone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new phthalazine derivatives 3a–i and 4a–c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a–c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 μmol.
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页码：3288 / 3293
页数：5
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