Modeling Pediatric Epilepsy Through iPSC-Based Technologies

被引：21

作者：

Simkin, Dina ^{[1
,2
]}

Kiskinis, Evangelos ^{[1
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, 303 East Chicago Ave,Ward 12-140, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA

来源：

EPILEPSY CURRENTS | 2018年 / 18卷 / 04期

关键词：

PLURIPOTENT STEM-CELLS; HUMAN BRAIN-DEVELOPMENT; ILAE COMMISSION; NEURONS; DISORDERS; SEIZURE; INDUCTION; ANGELMAN; CHANNELS; REVEALS;

D O I：

10.5698/1535-7597.18.4.240

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the current review, we discuss the process of modeling pediatric epileptic encephalopathies with a focus on in vitro iPSC-based technologies. We highlight the potential benefits as well as the challenges of these approaches and propose appropriate standards for the field.

引用

页码：240 / 245

页数：6

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