Modeling Pediatric Epilepsy Through iPSC-Based Technologies

被引：21

作者：

Simkin, Dina ^{[1
,2
]}

Kiskinis, Evangelos ^{[1
,3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, 303 East Chicago Ave,Ward 12-140, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA

来源：

EPILEPSY CURRENTS | 2018年 / 18卷 / 04期

关键词：

PLURIPOTENT STEM-CELLS; HUMAN BRAIN-DEVELOPMENT; ILAE COMMISSION; NEURONS; DISORDERS; SEIZURE; INDUCTION; ANGELMAN; CHANNELS; REVEALS;

D O I：

10.5698/1535-7597.18.4.240

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the current review, we discuss the process of modeling pediatric epileptic encephalopathies with a focus on in vitro iPSC-based technologies. We highlight the potential benefits as well as the challenges of these approaches and propose appropriate standards for the field.

引用

页码：240 / 245

页数：6

共 50 条

[1] Progress in iPSC-Based Modeling of Psychiatric Disorders
Hoffmann, Anke
Ziller, Michael
Spengler, Dietmar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (19)
[2] iPSC-based modeling of Parkinson's disease
Raya, A.
HUMAN GENE THERAPY, 2016, 27 (11) : A13 - A13
[3] Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders
Hoffmann, Anke
Ziller, Michael
Spengler, Dietmar
CELLS, 2020, 9 (02)
[4] iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy
Escriba, Ruben
Larranaga-Moreira, Jose M.
Richaud-Patin, Yvonne
Pourchet, Lea
Lazis, Ioannis
Jimenez-Delgado, Senda
Morillas-Garcia, Alba
Ortiz-Genga, Martin
Ochoa, Juan Pablo
Carreras, David
Perez, Guillermo Javier
de la Pompa, Jose Luis
Brugada, Ramon
Monserrat, Lorenzo
Barriales-Villa, Roberto
Raya, Angel
CIRCULATION RESEARCH, 2023, 133 (02) : 108 - 119
[5] Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications
Doss, Michael Xavier
Sachinidis, Agapios
CELLS, 2019, 8 (05)
[6] iPSC-Based Modeling of SCA12 for Targeted Therapeutic Screening
Roy, R.
Reddy, B.
Gerutshang, A.
Banerjee, R.
Chowdhury, S.
Kumar, H.
Chattarji, S.
MOVEMENT DISORDERS, 2024, 39 : S594 - S594
[7] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
Okano, Hideyuki
Morimoto, Satoru
CELL STEM CELL, 2022, 29 (02) : 189 - 208
[8] Promise and challenges of human iPSC-based hematologic disease modeling and treatment
Ye, Zhaohui
Chou, Bin-Kuan
Cheng, Linzhao
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2012, 95 (06) : 601 - 609
[9] iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous differentiation
Morey, Robert
Bui, Tony
Cheung, Virginia Chu
Dong, Chen
Zemke, Joseph E.
Requena, Daniela
Arora, Harneet
Jackson, Madeline G.
Pizzo, Donald
Theunissen, Thorold W.
Horii, Mariko
ISCIENCE, 2024, 27 (04)
[10] Promise and challenges of human iPSC-based hematologic disease modeling and treatment
Zhaohui Ye
Bin-Kuan Chou
Linzhao Cheng
International Journal of Hematology, 2012, 95 : 601 - 609

← 1 2 3 4 5 →