ASXL genes and RUNX1: an intimate connection?

被引：10
|
作者：
Metzeler, Klaus H. [1 ]
机构：
[1] Univ Munich, D-81377 Munich, Germany
来源：
BLOOD | 2014年 / 124卷 / 09期
关键词：
ACUTE MYELOID-LEUKEMIA; OLDER PATIENTS; MUTATIONS;
D O I：
10.1182/blood-2014-07-586073
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Micol et al report the discovery of mutations in the additional sex combs-like 2 (ASXL2) gene in about one-quarter of acute myeloid leukemia (AML) patients carrying the t(8;21) translocation.
引用
收藏
页码：1382 / 1383
页数：2
相关论文
共 50 条
  • [41] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
    Herglotz, J.
    Kuvardina, O. N.
    Kolodziej, S.
    Kumar, A.
    Hussong, H.
    Grez, M.
    Lausen, J.
    ONCOGENE, 2013, 32 (20) : 2565 - 2575
  • [42] RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes
    Koh, C. P.
    Wang, C. Q.
    Ng, C. E. L.
    Ito, Y.
    Araki, M.
    Tergaonkar, V.
    Huang, G.
    Osato, M.
    LEUKEMIA, 2013, 27 (09) : 1793 - 1802
  • [43] SLC22A4 and RUNX1: identification of RA susceptible genes
    Yamada, R
    Tokuhiro, S
    Chang, XT
    Yamamoto, K
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2004, 82 (09): : 558 - 564
  • [44] RUNX1/RUNX1T1 ORCHESTRATES THE LEUKAEMIC MICROENVIRONMENT
    Heidenreich, Olaf
    Derevyanko, Polina
    Krippner-Heidenreich, Anja
    Swart, Laura
    EXPERIMENTAL HEMATOLOGY, 2022, 111 : S93 - S93
  • [45] RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis
    Lam, Kentson
    Zhang, Dong-Er
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2012, 17 : 1120 - 1139
  • [46] Co-occurrence of RUNX1 and ASXL1 mutations underlie poor response and outcome for MDS patients treated with HMAs
    Wu, Ping
    Weng, Jianyu
    Li, Minming
    Lu, Zesheng
    Deng, Chengxin
    Sun, Qihui
    Xu, Ruohao
    Geng, Suxia
    Du, Xin
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2019, 11 (06): : 3651 - 3658
  • [47] RUNX1 Mutations in Myelodysplastic Syndrome
    Quesada, Andres E.
    Routbort, Mark
    Luthra, Rajyalakshmi
    Patel, Keyur
    Hidalgo-Lopez, Juliana E.
    Bueso-Ramos, Carlos
    Medeiros, L. Jeffrey
    Kanagal-Shamanna, Rashmi
    LABORATORY INVESTIGATION, 2018, 98 : 545 - 546
  • [48] Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia
    Prebet, Thomas
    Carbuccia, Nadine
    Raslova, Hana
    Favier, Remi
    Rey, Jerome
    Arnoulet, Christine
    Vey, Norbert
    Vainchenker, William
    Birnbaum, Daniel
    Mozziconacci, Marie-Joelle
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2013, 91 (03) : 277 - 279
  • [49] Mutant RUNX1 and histone tales
    Godley, Lucy A.
    BLOOD, 2017, 130 (20) : 2156 - 2157
  • [50] Runx1 expression in hematopoiesis.
    de Bruijn, M
    North, T
    Stacy, T
    Speck, N
    BLOOD, 2002, 100 (11) : 293A - 293A
12345