ASXL genes and RUNX1: an intimate connection?

被引:10
|
作者
Metzeler, Klaus H. [1 ]
机构
[1] Univ Munich, D-81377 Munich, Germany
关键词
ACUTE MYELOID-LEUKEMIA; OLDER PATIENTS; MUTATIONS;
D O I
10.1182/blood-2014-07-586073
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this issue of Blood, Micol et al report the discovery of mutations in the additional sex combs-like 2 (ASXL2) gene in about one-quarter of acute myeloid leukemia (AML) patients carrying the t(8;21) translocation.
引用
收藏
页码:1382 / 1383
页数:2
相关论文
共 50 条
  • [1] ANALYSIS OF MDS MICE MODEL INDUCED BY ASXL1 AND RUNX1 MUTANTS
    Nagase, Reim
    Inoue, Daichi
    Saika, Makoto
    Hou, Hsin-An
    Chou, Wen-Chien
    Kawabata, Kimihito
    Harada, Hironori
    Kanai, Akinori
    Goyama, Susumu
    Honda, Hiroaki
    Tien, Hwei-Fang
    Kitamura, Toshio
    EXPERIMENTAL HEMATOLOGY, 2016, 44 (09) : S90 - S90
  • [2] FUNCTIONAL STUDY ON THE COOPERATION OF ASXL1 AND RUNX1 MUTATIONS FOR LEUKEMIC TRANSFORMATION
    Bera, R.
    Liang, D. -C.
    Chiu, M. -C.
    Huang, Y. -J.
    Shih, L. -Y.
    HAEMATOLOGICA, 2017, 102 : 258 - 258
  • [3] RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
    Rabindranath Bera
    Ming-Chun Chiu
    Ying-Jung Huang
    Tung-Huei Lin
    Ming-Chung Kuo
    Lee-Yung Shih
    Journal of Hematology & Oncology, 12
  • [4] RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
    Bera, Rabindranath
    Chiu, Ming-Chun
    Huang, Ying-Jung
    Lin, Tung-Huei
    Kuo, Ming-Chung
    Shih, Lee-Yung
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (01)
  • [5] ASXL1 Mutation Cooperating with RUNX1 Mutation Further Perturbs the Differentiation of Neutrophils
    He, Jinping
    Liu, Qifa
    BLOOD, 2021, 138
  • [6] RUNX1 translocations and fusion genes in malignant hemopathies
    De Braekeleer, Etienne
    Douet-Guilbert, Nathalie
    Morel, Frederic
    Le Bris, Marie-Josee
    Ferec, Claude
    De Braekeleer, Marc
    FUTURE ONCOLOGY, 2011, 7 (01) : 77 - 91
  • [7] The Significance of ASXL1/RUNX1 Double Mutations in Myelodysplastic Syndromes: Even Worse Prognosis?
    Zhang, Hailing
    Hussaini, Mohammad
    Zhang, Xiaohui
    Shao, Haipeng
    Moscinski, Lynn
    Song, Jinming
    MODERN PATHOLOGY, 2017, 30 : 387A - 387A
  • [8] The Significance of ASXL1/RUNX1 Double Mutations in Myelodysplastic Syndromes: Even Worse Prognosis?
    Zhang, Hailing
    Hussaini, Mohammad
    Zhang, Xiaohui
    Shao, Haipeng
    Moscinski, Lynn
    Song, Jinming
    LABORATORY INVESTIGATION, 2017, 97 : 387A - 387A
  • [9] SIGNIFICANT ADVERSE PROGNOSIS IN THE SUBGROUP OF CMML PATIENTS WHO PRESENT MUTATIONS IN CERTAIN GENES (ASXL1, RUNX1, NRAS OR KRAS)
    Teresa, Cedena M.
    Maria, Pozas
    Irene, Zamanillo
    Rodrigo, Iniguez
    Fatima, Miras
    Cristina, Garcia-Sanchez
    Inmaculada, Rapado
    Rosa, Ayala M.
    HAEMATOLOGICA, 2021, 106 (10) : 251 - 252
  • [10] TdT plus Acute Myeloid Leukemia is enriched for mutations of RUNX1, BCOR, and ASXL1
    Bailey, Nathanael
    Carlsen, Eric
    Wild, Matthew
    Liu, Yen-Chun
    Djokic, Miroslav
    LABORATORY INVESTIGATION, 2019, 99