Cationic Pd(II) catalyzed regioselective intramolecular hydroarylation for the efficient synthesis of 4-aryl-2-quinolones

被引：21

作者：

Singh, Karandeep ^{[1
,2
]}

Malviya, Bhanwar Kumar ^{[1
]}

Verma, Ved Prakash ^{[3
]}

Badsara, Satpal Singh ^{[4
]}

Bhardwaj, Vimal K. ^{[5
]}

Sharma, Siddharth ^{[1
]}

机构：

[1] Mohanlal Sukhadia Univ, Dept Chem, Udaipur 313001, Rajasthan, India

[2] Guru Nanak Dev Univ, UGC Ctr Advance Studies Chem, Dept Chem, Amritsar 143005, Punjab, India

[3] Banasthali Univ, Dept Chem, Newai Jodhpuriya Rd, Vanasthali 304022, India

[4] Univ Rajasthan, Ctr Adv Study, Dept Chem, MFOS Lab, JLN Marg, Jaipur 302004, Rajasthan, India

[5] Natl Inst Technol Jalandhar, Dept Chem, Jalandhar 144011, Punjab, India

来源：

TETRAHEDRON | 2019年 / 75卷 / 17期

关键词：

Multi-component reaction; Ugi reaction; Isocyanide; Hydroarylation; Cyclization; Palladium catalyst; BIOAVAILABLE OXYTOCIN ANTAGONISTS; ONE-POT; MULTICOMPONENT REACTION; COMBINATORIAL SYNTHESIS; CASCADE REACTION; BETA-LACTAMS; METAL-FREE; DERIVATIVES; CYCLIZATION; 2,5-DIKETOPIPERAZINES;

D O I：

10.1016/j.tet.2019.03.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A divergent regioselective palladium (II) catalyzed approach through post Ugi cyclization is described. The Ugi adduct underwent intramolecular ortho-hydroarylation via 6-endo-dig cyclization for the direct access to 4-aryl-2-quinolones. Incorporation of iodine at the C-3 position of 2-quinolone followed by Suzuki-Miyaura coupling results into the more diversified 3,4-diaryl-2-quinolones. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：2506 / 2520

页数：15

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