Cationic Pd(II)-Catalyzed Tandem Reaction of 2-Arylethynylanilines and Aldehydes: An Efficient Synthesis of Substituted 3-Hydroxymethyl Indoles

被引：68
|
作者：
Han, Xiuling [1 ]
Lu, Xiyan [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 15期
基金：
中国国家自然科学基金;
关键词：
PALLADIUM-CATALYZED CYCLIZATION; FRIEDEL-CRAFTS REACTION; ARYLBORONIC ACIDS; PALLADIUM(II)-CATALYZED ADDITION; ARYLGLYCINE DERIVATIVES; HETEROCYCLES; ANNULATION; COMPLEXES;
D O I：
10.1021/ol1011086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient cationic palladium(II)-catalyzed synthesis of substituted 3-hydroxymethylindoles from readily accessible starting materials is developed. This tandem reaction involves an intramolecular aminopalladation of an alkyne and an addition to the carbonyl group to quench the carbon-palladium bond to complete the catalytic cycle without the necessity of a redox system.
引用
收藏
页码：3336 / 3339
页数：4
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