Synthesis of 2-Substituted Indoles via Migration Reaction of 3-Substituted Indoles with Triflic Acid

被引：0
|
作者：
Nakashima, Kosuke [1 ]
Kudo, Yuka [1 ]
Matsushima, Yasuyuki [1 ]
Hirashima, Shin-ichi [1 ]
Miura, Tsuyoshi [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2024年 / 72卷 / 03期
关键词：
indole; migration; 2-substituted indole; trifluoromethanesulfonic acid; HALOGEN DANCE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study showcases the 1,2-migration reactions of alkyl and aryl groups on the indole molecule. Trifluoromethanesulfonic acid effectively facilitates the migration of the substituent from C3- to C2-position of the indole structure. The resulting C2-substituted indoles offer a valuable pathway for the synthesis of natural products and medicinal compounds.
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页码：336 / 339
页数：4
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