Synthesis of 2-Substituted Indoles via Migration Reaction of 3-Substituted Indoles with Triflic Acid

被引：0

作者：

Nakashima, Kosuke ^{[1
]}

Kudo, Yuka ^{[1
]}

Matsushima, Yasuyuki ^{[1
]}

Hirashima, Shin-ichi ^{[1
]}

Miura, Tsuyoshi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2024年 / 72卷 / 03期

关键词：

indole; migration; 2-substituted indole; trifluoromethanesulfonic acid; HALOGEN DANCE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study showcases the 1,2-migration reactions of alkyl and aryl groups on the indole molecule. Trifluoromethanesulfonic acid effectively facilitates the migration of the substituent from C3- to C2-position of the indole structure. The resulting C2-substituted indoles offer a valuable pathway for the synthesis of natural products and medicinal compounds.

引用

页码：336 / 339

页数：4

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