Triple composite tumor of stomach: A rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma
A 50-year-old male patient presented with pain abdomen of 6 months duration. Computed tomography scan revealed a large mass in the stomach occluding the lumen. Histopathology revealed a triple composite tumor comprising of tubular adenocarcinoma arising on a background of high-grade dysplasia, hepatoid adenocarcinoma (positive for Hep Par-1 and alpha fetoprotein) and large cell neuroendocrine carcinoma (positive for synaptophysin and chromogranin) with nodal metastasis. Triple composite tumors are distinctly rare with few reports in literature.
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North Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
First Peoples Hosp Zigong, Dept Pathol, Zigong 643000, Peoples R ChinaNorth Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
Xu, Fang
Yu, Qin
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First Peoples Hosp Zigong, Dept Pathol, Zigong 643000, Peoples R ChinaNorth Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
Yu, Qin
Wan, Dan
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First Peoples Hosp Zigong, Dept Pathol, Zigong 643000, Peoples R ChinaNorth Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
Wan, Dan
Zhang, Yutao
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North Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
First Peoples Hosp Zigong, Dept Pathol, Zigong 643000, Peoples R ChinaNorth Sichuan Med Coll, Dept Pathol, Affiliated Hosp, Nanchong 637000, Peoples R China
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan
Lin, Kung-Hung
Chang, Nai-Jen
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Pathol, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan
Chang, Nai-Jen
Liou, Li-Ren
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan
Liou, Li-Ren
Su, Ming-Shan
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan
Su, Ming-Shan
Tsao, Min-Jen
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan
Tsao, Min-Jen
Huang, Meng-Lin
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Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, TaiwanKaohsiung Armed Forces Gen Hosp, Zuoying Branch, Div Gen Surg, Dept Surg, Kaohsiung, Taiwan