Radiation-induced inactivation of the angiotensin-converting enzyme in solutions 3. The effect of NaCl

被引：0
|
作者：
Orlova, MA [1 ]
Kost, OA [1 ]
Nikol'skaya, II [1 ]
Torshina, NN [1 ]
Binevski, PV [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 1999年 / 48卷 / 12期
关键词：
radiation-induced inactivation; angiotensin-converting enzyme; sodium chloride; radiation-induced activation; gamma-irradiation;
D O I：
10.1007/BF02498284
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effect of NaCl concentration (0--0.15 mol L-1) and gamma-irradiation dose on the catalytic activity of the angiotensin-converting enzyme is considered. Special regions in which a particular mechanism of dose response predominates are identified. In acid and alkaline media, there are regions of substantial enzymic activation; in addition, damped oscillations of the enzymic activity are observed. At pH 7.5, when the enzyme adopts;I more "unfolded" conformation, the clearly defined activation peaks on the surface relief are smoothed over, indicating a decrease in the effect of the salt concentration.
引用
收藏
页码：2334 / 2338
页数：5
相关论文
共 50 条
  • [41] RADIATION-INDUCED ALTERATIONS IN ANGIOTENSIN-CONVERTING ENZYME-ACTIVITY IN CULTURED BOVINE PULMONARY ARTERIAL ENDOTHELIAL-CELL MONOLAYERS
    PAPAPETROPOULOS, A
    BURCH, SE
    TOPOUZIS, S
    CATRAVAS, JD
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1993, 120 (01) : 96 - 105
  • [42] STRUCTURE-FUNCTION ANALYSIS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS AS MODIFIERS OF RADIATION-INDUCED PULMONARY ENDOTHELIAL DYSFUNCTION IN RATS
    WARD, WF
    MOLTENI, A
    KIM, YT
    TSAO, C
    BRITISH JOURNAL OF RADIOLOGY, 1989, 62 (736): : 348 - 354
  • [43] Angiotensin-Converting Enzyme N-Terminal Inactivation Alleviates Bleomycin-Induced Lung Injury
    Li, Ping
    Xiao, Hong D.
    Xu, Jianguo
    Ong, Frank S.
    Kwon, Mike
    Roman, Jesse
    Gal, Anthony
    Bernstein, Kenneth E.
    Fuchs, Sebastien
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (03): : 1113 - 1121
  • [44] RADIATION-INDUCED PULMONARY ENDOTHELIAL DYSFUNCTION IN RATS - MODIFICATION BY AN INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME
    WARD, WF
    KIM, YT
    MOLTENI, A
    SOLLIDAY, NH
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 15 (01): : 135 - 140
  • [45] Angiotensin-converting enzyme inhibitors for bevacizumab-induced hypertension
    Dincer, Murat
    Altundag, Kadri
    ANNALS OF PHARMACOTHERAPY, 2006, 40 (12) : 2278 - 2279
  • [46] Imaging findings in angiotensin-converting enzyme inhibitor induced angioedema
    Bhatt, Y. M.
    Aucott, W.
    EMERGENCY MEDICINE JOURNAL, 2011, 28 (07) : 589 - 589
  • [47] Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
    Pall, Amalie Hartvig
    Rasmussen, Eva Rye
    Wadelius, Mia
    PHARMACOGENOMICS, 2021, 22 (06)
  • [48] A CASE OF COUGHING INDUCED BY AN INHIBITOR OF THE ANGIOTENSIN-CONVERTING ENZYME IN THE DOG
    POUCHELON, JL
    GAILLOT, H
    RECUEIL DE MEDECINE VETERINAIRE, 1993, 169 (10) : 799 - 803
  • [49] Burning Mouth Syndrome Induced by Angiotensin-Converting Enzyme Inhibitors
    Obara, Takafumi
    Naito, Hiromichi
    Nojima, Tsuyoshi
    Koga, Hitoshi
    Nakao, Atsunori
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (11)
  • [50] LUNG INJURY INDUCED BY ANTIBODY FRAGMENTS TO ANGIOTENSIN-CONVERTING ENZYME
    CALDWELL, PRB
    WIGGER, HJ
    FERNANDEZ, LT
    DALISA, RM
    TSEENG, D
    BUTLER, VP
    GIGLI, I
    AMERICAN JOURNAL OF PATHOLOGY, 1981, 105 (01): : 54 - 63
12345