Radiation-induced inactivation of the angiotensin-converting enzyme in solutions 3. The effect of NaCl

被引：0
|
作者：
Orlova, MA [1 ]
Kost, OA [1 ]
Nikol'skaya, II [1 ]
Torshina, NN [1 ]
Binevski, PV [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 1999年 / 48卷 / 12期
关键词：
radiation-induced inactivation; angiotensin-converting enzyme; sodium chloride; radiation-induced activation; gamma-irradiation;
D O I：
10.1007/BF02498284
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effect of NaCl concentration (0--0.15 mol L-1) and gamma-irradiation dose on the catalytic activity of the angiotensin-converting enzyme is considered. Special regions in which a particular mechanism of dose response predominates are identified. In acid and alkaline media, there are regions of substantial enzymic activation; in addition, damped oscillations of the enzymic activity are observed. At pH 7.5, when the enzyme adopts;I more "unfolded" conformation, the clearly defined activation peaks on the surface relief are smoothed over, indicating a decrease in the effect of the salt concentration.
引用
收藏
页码：2334 / 2338
页数：5
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