Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

被引：10
|
作者：
McGlinchey, PG
Spence, MS
Patterson, CC
Allen, AR
Murphy, G
Belton, C
McKeown, PP
机构：
[1] Queens Univ Belfast, Inst Clin Sci, Dept Med, Belfast BT12 6BJ, Antrim, North Ireland
[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland
[3] Royal Victoria Hosp, Reg Med Cardiol Ctr, Belfast BT12 6BA, Antrim, North Ireland
来源：
TISSUE ANTIGENS | 2004年 / 64卷 / 02期
关键词：
gene polymorphism; ischaemic heart disease; MCP-1;
D O I：
10.1111/j.0001-2815.2004.00281.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.
引用
下载
收藏
页码：199 / 203
页数：5
相关论文
共 50 条
  • [41] The −2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients
    Emilia Saint Martin
    Emilce E. Schneeberger
    Federico M. Aranda
    Silvia Wingeyer Peres
    María del Carmen Valerio
    Maria de los Angeles Correa
    Fernando Dal Pra
    Liliana Martinez
    Graciela Remondino
    Gabriela de Larrañaga
    Gustavo Citera
    Clinical Rheumatology, 2016, 35 : 3057 - 3061
  • [42] Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis
    Nakashima, H
    Akahoshi, M
    Shimizu, S
    Inoue, Y
    Miyake, K
    Ninomiya, I
    Igawa, T
    Sadanaga, A
    Otsuka, T
    Harada, M
    LUPUS, 2004, 13 (03) : 165 - 167
  • [43] Association between MCP-1-2518A>G polymorphism and asthma susceptibility: a meta-analysis
    Chen, Wenli
    Cui, Jiewei
    Xiang, Guoan
    Zhang, Jianpeng
    Gao, Hongmei
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2019, 52 (11)
  • [44] Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population
    Zhu, X. L.
    Meng, H. X.
    Zhang, L.
    Xu, L.
    Chen, Z. B.
    Shi, D.
    Feng, X. H.
    Zhang, X.
    JOURNAL OF PERIODONTAL RESEARCH, 2012, 47 (03) : 286 - 292
  • [45] Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD):: family-based association study in a Spanish population
    González-Pérez, E
    Via, M
    López-Alomar, A
    Esteban, E
    Valveny, N
    Bao, M
    Domingo, E
    Moral, P
    CLINICAL GENETICS, 2002, 62 (03) : 235 - 239
  • [46] Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish type 2 diabetes patients with nephropathy
    Karadeniz, M.
    Erdogan, M.
    Cetinkalp, Sevki
    Berdeli, A.
    Eroglu, Z.
    Ozgen, A. G.
    ENDOCRINE, 2010, 37 (03): : 513 - 517
  • [47] Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis
    Wei-wei Chang
    Liu Zhang
    Li-ying Wen
    Yu-jing Tao
    Jia-jie Xiong
    Xin Tong
    Yue-long Jin
    Hong Su
    BMC Endocrine Disorders, 23
  • [48] Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish type 2 diabetes patients with nephropathy
    M. Karadeniz
    M. Erdogan
    Sevki Cetinkalp
    A. Berdeli
    Z. Eroglu
    A. G. Ozgen
    Endocrine, 2010, 37 : 513 - 517
  • [49] The GG genotype of the-2518 A/G polymorphism of the monocyte chemoattractant protein-1 (MCP-1) gene is a risk factor for ischemic stroke
    Flex, A
    Pola, R
    Gaetani, E
    Proia, AS
    Angela, DG
    Pecorini, G
    Straface, G
    Papaleo, P
    Serricchio, M
    Pola, P
    CIRCULATION, 2003, 108 (17) : 603 - 603
  • [50] The-2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients
    Saint Martin, Emilia
    Schneeberger, Emilce E.
    Aranda, Federico M.
    Wingeyer Peres, Silvia
    del Carmen Valerio, Maria
    de los Angeles Correa, Maria
    Dal Pra, Fernando
    Martinez, Liliana
    Remondino, Graciela
    de Larranaga, Gabriela
    Citera, Gustavo
    CLINICAL RHEUMATOLOGY, 2016, 35 (12) : 3057 - 3061
12345