Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

被引：10
|
作者：
McGlinchey, PG
Spence, MS
Patterson, CC
Allen, AR
Murphy, G
Belton, C
McKeown, PP
机构：
[1] Queens Univ Belfast, Inst Clin Sci, Dept Med, Belfast BT12 6BJ, Antrim, North Ireland
[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland
[3] Royal Victoria Hosp, Reg Med Cardiol Ctr, Belfast BT12 6BA, Antrim, North Ireland
来源：
TISSUE ANTIGENS | 2004年 / 64卷 / 02期
关键词：
gene polymorphism; ischaemic heart disease; MCP-1;
D O I：
10.1111/j.0001-2815.2004.00281.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.
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页码：199 / 203
页数：5
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