Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

被引：10

作者：

McGlinchey, PG

Spence, MS

Patterson, CC

Allen, AR

Murphy, G

Belton, C

McKeown, PP

机构：

[1] Queens Univ Belfast, Inst Clin Sci, Dept Med, Belfast BT12 6BJ, Antrim, North Ireland

[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland

[3] Royal Victoria Hosp, Reg Med Cardiol Ctr, Belfast BT12 6BA, Antrim, North Ireland

来源：

TISSUE ANTIGENS | 2004年 / 64卷 / 02期

关键词：

gene polymorphism; ischaemic heart disease; MCP-1;

D O I：

10.1111/j.0001-2815.2004.00281.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.

引用

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页码：199 / 203

页数：5

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