TLC-UV and -VIS Densitometric Detection Method for Determination of Oxyphenonium Bromide and its Degradation Products in Tablets

被引：0

作者：

Hubicka, Urszula ^{[1
]}

Krzek, Jan ^{[1
]}

Szczyrbowska, Olga ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Inorgan & Analyt Chem, Coll Med, PL-30688 Krakow, Poland

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2009年 / 32卷 / 09期

关键词：

Degradation products; Densitometry; Drug analysis; Oxyphenonium bromide; TLC; QUATERNARY AMMONIUM DRUGS; PAIR LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; REVERSED-PHASE; URINE; PLASMA;

D O I：

10.1080/10826070902854813

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A chromatographic-densitometric method was developed for determination of oxyhyphenonium bromide and its degradation products under UV/VIS spectra. Silica gel TLCF254 plates were used as stationary phase and butanol-1-glacial acetic acid-water (12.8:2:2.8 v/v/v) as mobile phase. Densitometric measurements were done at 225nm and 530nm. Degradation products -cyclohexyl--hydroxybenzeneacetic acid and N,N-diethyl-N-methylaminethanol were determined by 1HNMR method. The chromatographic-densitometric method is specific for studied compounds. Besides, it is shown that this method is very sensitive, precise, and has a broad range of linearity.

引用

页码：1196 / 1209

页数：14

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