Safety, Efficacy, and Determination of the Recommended Phase 2 Dose for the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330)

被引:0
|
作者
Chen, Christine [1 ]
Garzon, Ramiro [2 ]
Gutierrez, Martin [3 ]
Jacoby, Meagan A. [4 ]
Brown, Peter [5 ]
Flinn, Ian [6 ]
Stone, Richard M. [7 ]
Savoie, Mary Lynn [8 ]
Baz, Rachid [9 ]
Gabrail, Nashat Y. [10 ]
Wang, Michael [11 ]
Martin, Peter [12 ]
Siegel, David [13 ]
Mau-Sorensen, Morten [5 ]
Andreef, Michael [14 ]
Marshall, Tracey [15 ]
Saint-Martin, Jean-Richard [15 ]
Carlson, Robert [15 ]
Shacham, Sharon [16 ]
Kauffman, Michael [15 ]
Kuruvilla, John [17 ]
机构
[1] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada
[2] Ohio State Univ, Columbus, OH 43210 USA
[3] John Theurer Canc Ctr, Hackensack, NJ USA
[4] Washington Univ, Dept Med, Div Oncol, St Louis, MO USA
[5] Univ Copenhagen Hosp, Rigshosp, DK-2100 Copenhagen, Denmark
[6] Sarah Cannon Res Inst, Nashville, TN USA
[7] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[8] Univ Calgary, Calgary, AB, Canada
[9] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA
[10] Gabrail Canc Ctr, Canton, OH USA
[11] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA
[12] Weill Cornell Med Coll, Div Hematol Oncol, New York, NY USA
[13] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA
[14] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[15] Karyopharm Therapeut, Newton, MA USA
[16] Karyopharm Therapeut Inc, Newton, MA USA
[17] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma
    Abbey R. Sadowski
    Heather L. Gardner
    Antonella Borgatti
    Heather Wilson
    David M. Vail
    Joshua Lachowicz
    Christina Manley
    Avenelle Turner
    Mary K. Klein
    Angharad Waite
    Alexandra Sahora
    Cheryl A. London
    BMC Veterinary Research, 14
  • [42] The efficacy of selinexor (KPT-330), an XPO1 inhibitor, on non-hematologic cancers: a comprehensive review
    Jennifer R. Landes
    Stephen A. Moore
    Brooke R. Bartley
    Hung Q. Doan
    Peter L. Rady
    Stephen K. Tyring
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 2139 - 2155
  • [43] Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma
    Sadowski, Abbey R.
    Gardner, Heather L.
    Borgatti, Antonella
    Wilson, Heather
    Vail, David M.
    Lachowicz, Joshua
    Manley, Christina
    Turner, Avenelle
    Klein, Mary K.
    Waite, Angharad
    Sahora, Alexandra
    London, Cheryl A.
    BMC VETERINARY RESEARCH, 2018, 14
  • [44] Effect of selinexor (KPT-330), a novel oral selective inhibitor of nuclear export (SINE), on tumor suppressors and cell cycle proteins in prostate cancer cells and regression of castration-resistant patient-derived xenograft tumor growth.
    Maity, Sankar N.
    Wu, Guanglin
    Lu, Jing-Fang
    Anh Hoang
    Landesman, Yosef
    McCauley, Dilara
    Carlson, Robert
    Rashal, Tami
    Shacham, Sharon
    Broom, Bradley McIntosh
    Baggerly, Keith A.
    Aparicio, Ana
    Efstathiou, Eleni
    Araujo, John C.
    Logothetis, Christopher
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (07)
  • [45] Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Of a First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin's Lyphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
    Kuruvilla, John
    Gutierrez, Martin
    Shah, Bijal D.
    Gabrail, Nashat Y.
    Brown, Peter de Nully
    Stone, Richard M.
    Garzon, Ramiro
    Savona, Michael
    Siegel, David S.
    Baz, Rachid
    Mau-Sorensen, Morten
    Davids, Matthew S.
    Byrd, John C.
    Shacham, Sharon
    Rashal, Tami
    Yau, Cindy Y. F.
    McCauley, Dilara
    Saint-Martin, Jean-Richard
    McCartney, John
    Landesman, Yosef
    Klebanov, Boris
    Pond, Greg
    Oza, Amit M.
    Kauffman, Michael
    Mirza, Mansoor R.
    BLOOD, 2013, 122 (21)
  • [46] Selinexor, a selective inhibitor of nuclear export (SINE), in patients with unresectable melanoma.
    Kendra, Kari Lynn
    Watson, Ryan
    Lesinski, Gregory B.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [47] Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom's Macroglobulinemia (WM)
    Chen, Christine I.
    Gutierrez, Martin
    Brown, Peter de Nully
    Gabrail, Nashat
    Baz, Rachid
    Reece, Donna E.
    Savona, Michael
    Trudel, Suzanne
    Siegel, David S.
    Mau-Sorensen, Morten
    Kuruvilla, John
    Byrd, John C.
    Shacham, Sharon
    Rashal, Tami
    Yau, Cindy Y. F.
    McCauley, Dilara
    Landesman, Yosef
    Klebanov, Boris
    Pond, Greg
    Oza, Amit M.
    Kauffman, Michael
    Mirza, Mansoor R.
    BLOOD, 2013, 122 (21)
  • [48] Nuclear Export Inhibition for Radiosensitization: A Proof-of-Concept Phase 1 Clinical Trial of Selinexor (KPT-330) Combined With Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
    Lawrence, Yaacov R.
    Shacham-Shmueli, Einat
    Yarom, Nirit
    Khaikin, Marat
    Venturero, Moris
    Apter, Sara
    Inbar, Yael
    Symon, Zvi
    Aderka, Dan
    Halpern, Naama
    Berger, Raanan
    Boursi, Ben
    Jacobson, Galia
    Raskin, Stephen
    Ackerstein, Aliza
    Margalit, Ofer
    Appel, Sarit
    Schvimer, Michael
    Crochiere, Marsha
    Yang, Fan
    Landesman, Yosef
    Rashal, Tami
    Shacham, Sharon
    Golan, Talia
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2022, 114 (02): : 250 - 255
  • [49] Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
    Vinod Vijay Subhash
    Mei Shi Yeo
    Lingzhi Wang
    Shi Hui Tan
    Foong Ying Wong
    Win Lwin Thuya
    Woei Loon Tan
    Praveen C. Peethala
    Mu Yar Soe
    David S. P. Tan
    Nisha Padmanabhan
    Erkan Baloglu
    Sharon Shacham
    Patrick Tan
    H. Phillip Koeffler
    Wei Peng Yong
    Scientific Reports, 8
  • [50] Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
    Subhash, Vinod Vijay
    Yeo, Mei Shi
    Wang, Lingzhi
    Tan, Shi Hui
    Wong, Foong Ying
    Thuya, Win Lwin
    Tan, Woei Loon
    Peethala, Praveen C.
    Soe, Mu Yar
    Tan, David S. P.
    Padmanabhan, Nisha
    Baloglu, Erkan
    Shacham, Sharon
    Tan, Patrick
    Koeffler, H. Phillip
    Yong, Wei Peng
    SCIENTIFIC REPORTS, 2018, 8