Safety, Efficacy, and Determination of the Recommended Phase 2 Dose for the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330)

被引：0

作者：

Chen, Christine ^{[1
]}

Garzon, Ramiro ^{[2
]}

Gutierrez, Martin ^{[3
]}

Jacoby, Meagan A. ^{[4
]}

Brown, Peter ^{[5
]}

Flinn, Ian ^{[6
]}

Stone, Richard M. ^{[7
]}

Savoie, Mary Lynn ^{[8
]}

Baz, Rachid ^{[9
]}

Gabrail, Nashat Y. ^{[10
]}

Wang, Michael ^{[11
]}

Martin, Peter ^{[12
]}

Siegel, David ^{[13
]}

Mau-Sorensen, Morten ^{[5
]}

Andreef, Michael ^{[14
]}

Marshall, Tracey ^{[15
]}

Saint-Martin, Jean-Richard ^{[15
]}

Carlson, Robert ^{[15
]}

Shacham, Sharon ^{[16
]}

Kauffman, Michael ^{[15
]}

Kuruvilla, John ^{[17
]}

机构：

[1] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada

[2] Ohio State Univ, Columbus, OH 43210 USA

[3] John Theurer Canc Ctr, Hackensack, NJ USA

[4] Washington Univ, Dept Med, Div Oncol, St Louis, MO USA

[5] Univ Copenhagen Hosp, Rigshosp, DK-2100 Copenhagen, Denmark

[6] Sarah Cannon Res Inst, Nashville, TN USA

[7] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[8] Univ Calgary, Calgary, AB, Canada

[9] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA

[10] Gabrail Canc Ctr, Canton, OH USA

[11] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[12] Weill Cornell Med Coll, Div Hematol Oncol, New York, NY USA

[13] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA

[14] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[15] Karyopharm Therapeut, Newton, MA USA

[16] Karyopharm Therapeut Inc, Newton, MA USA

[17] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada

来源：

BLOOD | 2015年 / 126卷 / 23期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 50 条

[21] Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
J Etchin
J Montero
A Berezovskaya
B T Le
A Kentsis
A L Christie
A S Conway
W C Chen
C Reed
M R Mansour
C E L Ng
S Adamia
S J Rodig
I A Galinsky
R M Stone
B Klebanov
Y Landesman
M Kauffman
S Shacham
A L Kung
J C Y Wang
A Letai
A T Look
Leukemia, 2016, 30 : 0 - 0
[22] THE ORAL SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SELINEXOR (KPT-330) ACTIVITY IN DOUBLE HIT DIFFUSE LARGE B CELL LYMPHOMAS (DLBCL) IN PRECLINICAL MODELS & CLINICAL ACTIVITY IN PATIENTS WITH DLBCL
Kuruvilla, J.
Cerchietti, L.
Wagner-Johnston, N.
Stone, R.
Jacobsen, E.
Mau-Sorensen, M.
Brown, P.
Baz, R.
Shal, B.
Flynn, J.
Flinn, I.
Kukreti, V.
Tiedemann, R.
Goy, A.
Landesman, Y.
Klebanov, B.
Shacham, E.
Saint-Martin, J. R.
Marshall, T.
McCartney, J.
McCauley, D.
Carlson, R.
Rebello, S.
Rashal, T.
Mirza, M. R.
Shacham, S.
Kauffman, M.
Gutierrez, M.
HAEMATOLOGICA, 2014, 99 : 152 - 152
[23] Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice
Etchin, J.
Montero, J.
Berezovskaya, A.
Le, B. T.
Kentsis, A.
Christie, A. L.
Conway, A. S.
Chen, W. C.
Reed, C.
Mansour, M. R.
Ng, C. E. L.
Adamia, S.
Rodig, S. J.
Galinsky, I. A.
Stone, R. M.
Klebanov, B.
Landesman, Y.
Kauffman, M.
Shacham, S.
Kung, A. L.
Wang, J. C. Y.
Letai, A.
Look, A. T.
LEUKEMIA, 2016, 30 (01) : 190 - 199
[24] Safety and antitumor activity of selinexor (KPT-330), a first-in -class, oral XPO1 selective inhibitor of nuclear export: A phase I study expanded with colon cancer cohort.
Mau-Soerensen, Morten
Razak, Albiruni R. A.
Mahipal, Amit
Mahaseth, Hemchandra
Gerecitano, John F.
Shacham, Sharon
Yau, Cindy Y. F.
Lassen, Ulrik
Shields, Anthony Frank
McCauley, Dilara
Cooksey, Jennifer
Tan, David Shao Peng
Rashal, Tami
Shacham, Eran
Landesman, Yosef
Pond, Gregory
Oza, Amit M.
Kauffman, Michael
Siu, Lillian
Mirza, Mansoor Raza
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (03)
[25] TOPICAL SELINEXOR (KPT-330), A SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SHOWS INCREASED BLOOD FLOW AND ACCELERATED HEALING USING NONINVASIVE TECHNIQUES IN AN ISCHEMIC MODEL OF WOUND HEALING
Ganesh, K.
Kitsos, C.
Rashal, T.
Roy, S.
Gnyawali, S.
Friedlander, S.
Chen, W.
Ellis, J.
Austad, B.
McCauley, D.
Kauffman, M.
Shacham, S.
Sen, C.
WOUND REPAIR AND REGENERATION, 2015, 23 (02) : A22 - A22
[26] A first-in-class, first-in-human phase I trial of KPT-330 (selinexor), a selective inhibitor of unclear export (SINE) in patients (pis) with advanced solid tumors
Mau-Soerensen, Morten
Razak, Albiruni R. A.
Shields, Anthony Frank
Gabrall, Nashat Y.
Gereeltano, John F.
Shacham, Sharon
Lassen, Ulrlk Niels
Rashal, Taml
Cooksoy, Jennifer
Landosman, Yosof
Pond, Gregory
Oza, Amit M.
Kauffman, Michael
Siu, Lillian L.
Bedard, Philippe L.
Mahaseth, Hemchandra
Mlrza, Mansoor Raza
Mahipal, Arnit
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[27] Nuclear export inhibitor selinexor (KPT-330) demonstrates anti-tumor efficacy alone and in combination with chemotherapy in multiple breast cancer models
Arango, Natalia Paez
Evans, Kurt
Zhao, Ming
Yuca, Erkan
Scott, Stephen
Kim, Charissa
Naing, Aung
Meric-Bernstam, Funda
CANCER RESEARCH, 2016, 76
[28] Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer
Kazim, Sabiha
Malafa, Mokenge P.
Coppola, Domenico
Husain, Kazim
Zibadi, Sherma
Kashyap, Trinayan
Crochiere, Marsha
Landesman, Yosef
Rashal, Tami
Sullivan, Daniel M.
Mahipal, Amit
MOLECULAR CANCER THERAPEUTICS, 2015, 14 (07) : 1570 - 1581
[29] Preclinical and early clinical activity of the oral selective inhibitor of nuclear export (SINE) exportin I (XPOI) antagonist KPT-330 (Selinexor) in patients (pts) with platinum-resistant/refractory ovarian cancer (OvCa).
Martignetti, John
Razak, Albiruni R. A.
Chen, Ying
Gabrail, Nashat Y.
Gerecitano, John F.
Camacho, Catalina
Pereira, Elena
Dottino, Peter Remsen
Shacham, Sharon
McCauley, Dilara
Rashal, Tami
Saint-Martin, Jean-Richard
Shacham, Eran
Vincett, Darcy
Kauffman, Michael
Mirza, Mansoor Raza
Sorensen, Morten
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[30] THE COMBINATION OF SELINEXOR (KPT-330), A SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE), & THE FLT3 INHIBITOR QUIZATINIB SHOWS ANTI-TUMOR ACTIVITY IN ACUTE MYELOID LEUKEMIA (AML) IN VITRO AND IN VIVO
Carlson, R.
Senapedis, W.
Landesman, Y.
Shacham, S.
HAEMATOLOGICA, 2014, 99 : 290 - 291

← 1 2 3 4 5 →