Safety, Efficacy, and Determination of the Recommended Phase 2 Dose for the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330)

被引：0

作者：

Chen, Christine ^{[1
]}

Garzon, Ramiro ^{[2
]}

Gutierrez, Martin ^{[3
]}

Jacoby, Meagan A. ^{[4
]}

Brown, Peter ^{[5
]}

Flinn, Ian ^{[6
]}

Stone, Richard M. ^{[7
]}

Savoie, Mary Lynn ^{[8
]}

Baz, Rachid ^{[9
]}

Gabrail, Nashat Y. ^{[10
]}

Wang, Michael ^{[11
]}

Martin, Peter ^{[12
]}

Siegel, David ^{[13
]}

Mau-Sorensen, Morten ^{[5
]}

Andreef, Michael ^{[14
]}

Marshall, Tracey ^{[15
]}

Saint-Martin, Jean-Richard ^{[15
]}

Carlson, Robert ^{[15
]}

Shacham, Sharon ^{[16
]}

Kauffman, Michael ^{[15
]}

Kuruvilla, John ^{[17
]}

机构：

[1] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada

[2] Ohio State Univ, Columbus, OH 43210 USA

[3] John Theurer Canc Ctr, Hackensack, NJ USA

[4] Washington Univ, Dept Med, Div Oncol, St Louis, MO USA

[5] Univ Copenhagen Hosp, Rigshosp, DK-2100 Copenhagen, Denmark

[6] Sarah Cannon Res Inst, Nashville, TN USA

[7] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[8] Univ Calgary, Calgary, AB, Canada

[9] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33612 USA

[10] Gabrail Canc Ctr, Canton, OH USA

[11] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[12] Weill Cornell Med Coll, Div Hematol Oncol, New York, NY USA

[13] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA

[14] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[15] Karyopharm Therapeut, Newton, MA USA

[16] Karyopharm Therapeut Inc, Newton, MA USA

[17] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada

来源：

BLOOD | 2015年 / 126卷 / 23期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 50 条

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[3] A PHASE 1 DOSE ESCALATION STUDY OF THE ORAL SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SELINEXOR (KPT-330) IN PATIENTS (PTS) WITH RELAPSED / REFRACTORY ACUTE MYELOID LEUKEMIA (AML)
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[4] A phase I dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with relapsed/refractory acute myeloid leukemia (AML).
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[5] KCP-330-005/SIGN: A PHASE II, OPEN-LABEL STUDY OF EFFICACY AND SAFETY OF THE SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) KPT-330 (SELINEXOR) IN PATIENTS WITH ADVANCED GYNAECOLOGIC MALIGNANCIES
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[9] Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo
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[10] Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)
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