New chiral Schiff base as a tridentate ligand for catalytic enantioselective addition of diethylzinc to aldehydes

被引：69
|
作者：
Tanaka, Takanori [1 ]
Yasuda, Yorinobu [1 ]
Hayashi, Masahiko [1 ]
机构：
[1] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 18期
关键词：
D O I：
10.1021/jo060964u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed new chiral Schiff base catalysts for the enantioselective addition of diethylzinc reagents to aldehydes. The reaction of benzaldehyde with diethylzinc in the presence of 1 mol % of the chiral Schiff base catalyst proceeded to afford 1-phenyl-1-propanol in 96% enantiomeric excess (ee).
引用
收藏
页码：7091 / 7093
页数：3
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