GC-MS Analysis and Activity Study of the Volatile Components of Huidouba

被引:0
|
作者
Li, Lixia [1 ]
Fu, Tingting [1 ]
Wang, Qiang [2 ]
Zou, Yuanfeng [1 ]
Huang, Chao [1 ]
Yin, Zhongqiong [1 ]
Yang, Jiao [1 ]
Liu, Yang [1 ]
Feng, Dongmei [1 ]
Feng, Xin [1 ]
机构
[1] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Sichuan, Peoples R China
[2] Sichuan Agr Univ, Inst Ecol Agr, Chengdu 611130, Sichuan, Peoples R China
关键词
Traditional Chinese medicine; Huidouba; GC-MS; volatile composition; protein docking; PHYTOL; RECEPTOR;
D O I
10.1080/0972060X.2017.1365016
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The volatile oil extracted from the traditional Chinese medicine, Huidouba, was analyzed by gas chromatography-mass spectrometry (GC-MS) and the mass fractions of all these chemical components were tested by using peak area normalization method. 103 chemical compositions in total were identified, which accounted for 87.296 % of the total amount of the volatile oil, mainly including hydrocarbons for 52.646%, alcohols for 15.483 %, phenols for 6.205 %, ketones for 1.211 %, aldehydes for 4.718 % esters for 6.573 %and nitrogenous substances for 0.46 %.The analysis using AutoDock 4.2 showed that ferruginol was docked with the hemeoxygenase (1S8C), alpha-patchoulene was docked with the human sorbitol dehydrogenase (1PL7), vitamin A aldehyde was docked with the human retinal receptor (1EXX), phytol was docked with the natural anticoagulant (1LQV),and alpha-copaene was docked with the hexameric insulin (1TYL).Which play important roles in health, implicating the potential activity of these components in Huidouba volatile in diabetes treatment.
引用
收藏
页码:476 / 484
页数:9
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