Cancer Detection with Surface Plasmon Resonance-Based Photonic Crystal Fiber Biosensor

被引：95

作者：

Yasli, Ahmet ^{[1
]}

机构：

[1] European Univ Lefke, Elect & Elect Engn Dept, TR-10 Lefke, Turkey

来源：

PLASMONICS | 2021年 / 16卷 / 05期

关键词：

Fiber optic biosensor; Photonic crystal fiber (PCF); Surface plasmon resonance (SPR); Cancer cell; CONFINEMENT LOSSES; BREAST-CANCER; SENSOR; CELLS; CLASSIFICATION; DESIGN; SILVER; SPR;

D O I：

10.1007/s11468-021-01425-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, early cancer detection of a single living cell is investigated by employing a surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) biosensor structure. The full-vectorial finite element method (FV-FEM) with perfectly matched layers are engaged for numerical analysis. The spectral interrogation and amplitude methods are used to detect the refractive index (RI) variations of cancer cells. The refractive index (RI) varied from 1.392 to 1.401 for six different types of cancerous cells. Obtained numerical results have indicated that, the highest sensitivities for spectral interrogation and amplitude methods are reported as 7142.86nm/RIU for MCF-7, and -757 RIU-1 for Hela cell, respectively.

引用

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页码：1605 / 1612

页数：8

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