Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-1

被引：14

作者：

Rother, Sandra ^{[1
]}

Kroenert, Vera ^{[1
]}

Hauck, Nicolas ^{[2
]}

Berg, Albrecht ^{[3
]}

Moeller, Stephanie ^{[3
]}

Schnabelrauch, Matthias ^{[3
]}

Thiele, Julian ^{[2
]}

Scharnweber, Dieter ^{[1
]}

Hintze, Vera ^{[1
]}

机构：

[1] Tech Univ Dresden, Inst Mat Sci, Max Bergmann Ctr Biomat, Budapester Str 27, D-01069 Dresden, Germany

[2] Leibniz Inst Polymerforsch Dresden eV, Inst Phys Chem & Polymer Phys, D-01069 Dresden, Germany

[3] INNOVENT eV, Biomat Dept, Prussingstr 27B, D-07745 Jena, Germany

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2019年 / 30卷 / 06期

关键词：

Hyaluronic acid - Hydrogels;

D O I：

10.1007/s10856-019-6267-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hyaluronan (HA)-based microgels generated in a microfluidic approach, containing an artificial extracellular matrix composed of collagen and high-sulfated hyaluronan (sHA3), were incorporated into a HA/collagen-based hydrogel matrix. This significantly enhanced the retention of noncrosslinked sHA3 within the gels enabling controlled sHA3 presentation. Gels containing sHA3 bound higher amounts of transforming growth factor-1 (TGF-1) compared to pure HA/collagen hydrogels. Moreover, the presence of sHA3-containing microgels improved the TGF-1 retention within the hydrogels. These findings are promising for developing innovative biomaterials with adjustable sHA3 release and growth factor interaction profiles to foster skin repair, e.g., by rebalancing dysregulated TGF-1 levels. [GRAPHICS] .

引用

页数：5

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