Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-1

被引：14
|
作者：
Rother, Sandra [1 ]
Kroenert, Vera [1 ]
Hauck, Nicolas [2 ]
Berg, Albrecht [3 ]
Moeller, Stephanie [3 ]
Schnabelrauch, Matthias [3 ]
Thiele, Julian [2 ]
Scharnweber, Dieter [1 ]
Hintze, Vera [1 ]
机构：
[1] Tech Univ Dresden, Inst Mat Sci, Max Bergmann Ctr Biomat, Budapester Str 27, D-01069 Dresden, Germany
[2] Leibniz Inst Polymerforsch Dresden eV, Inst Phys Chem & Polymer Phys, D-01069 Dresden, Germany
[3] INNOVENT eV, Biomat Dept, Prussingstr 27B, D-07745 Jena, Germany
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2019年 / 30卷 / 06期
关键词：
Hyaluronic acid - Hydrogels;
D O I：
10.1007/s10856-019-6267-1
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Hyaluronan (HA)-based microgels generated in a microfluidic approach, containing an artificial extracellular matrix composed of collagen and high-sulfated hyaluronan (sHA3), were incorporated into a HA/collagen-based hydrogel matrix. This significantly enhanced the retention of noncrosslinked sHA3 within the gels enabling controlled sHA3 presentation. Gels containing sHA3 bound higher amounts of transforming growth factor-1 (TGF-1) compared to pure HA/collagen hydrogels. Moreover, the presence of sHA3-containing microgels improved the TGF-1 retention within the hydrogels. These findings are promising for developing innovative biomaterials with adjustable sHA3 release and growth factor interaction profiles to foster skin repair, e.g., by rebalancing dysregulated TGF-1 levels. [GRAPHICS] .
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页数：5
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