Terpenoids from Vitex trifolia and their anti-inflammatory activities

被引：13

作者：

Bao, Fengyan ^{[1
]}

Tang, Ruotian ^{[2
]}

Cheng, Li ^{[1
]}

Zhang, Cuiyun ^{[1
]}

Qiu, Chongyue ^{[1
]}

Yuan, Ting ^{[1
]}

Zhu, Lihan ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Wuya Coll Innovat,Minist Educ, Shenyang 110016, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2018年 / 72卷 / 02期

关键词：

Vitex trifolia L; Diterpenoid; Iridoid; Anti-inflammatory effect; MEDICINAL-PLANTS; DITERPENOIDS; FRUITS; GLYCOSIDE; IRIDOIDS;

D O I：

10.1007/s11418-018-1178-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-beta-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6 beta-dihydroxy iridoid 1-O-beta-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 mu M, respectively.

引用

页码：570 / 575

页数：6

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