Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

被引：24

作者：

Watts, Fiona ^{[1
]}

Tan, Lay Ean ^{[2
,5
]}

Wilson, Clive G. ^{[2
]}

Girkin, John M. ^{[3
]}

Tassieri, Manlio ^{[4
]}

Wright, Amanda J. ^{[1
,6
]}

机构：

[1] Univ Strathclyde, Inst Photon, SUPA, Glasgow G4 0NW, Lanark, Scotland

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biol Sci, Glasgow G4 0NR, Lanark, Scotland

[3] Univ Durham, Dept Phys, Biophys Sci Inst, Durham DH1 3LE, England

[4] Univ Glasgow, Sch Engn, Div Biomed Engn, Glasgow G12 8LT, Lanark, Scotland

[5] Ferring Controlled Therapeut Ltd, E Kilbride G74 5PB, Lanark, Scotland

[6] Univ Nottingham, IBIOS, Nottingham NG7 2RD, England

来源：

JOURNAL OF OPTICS | 2014年 / 16卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

optical trapping; micro-rheology; vitreous humor; COMPLEX FLUIDS; TWEEZERS; VISCOSITY; FORCE; MICRORHEOLOGY;

D O I：

10.1088/2040-8978/16/1/015301

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

引用

页数：7

共 17 条

[11] Attitudinal manipulation of an optically trapped bacillary probe by controlling the distance between focal points for local dosing in cells
Yasokawa, Toshiki
Ishimaru, Ichirou
Nakagawa, Yuki
Kuriyama, Shigeki
Masaki, Tsutomu
Nakai, Seiji
Takegawa, Kaoru
Tanaka, Naotaka
APPLIED PHYSICS LETTERS, 2006, 89 (13)
[12] MICRO-RHEOLOGY CHANGES OF NAFION(R) FILMS WITH ELECTROCHEMICAL MASS-TRANSPORT IN HYDROQUINONE SOLUTIONS AND IN SITU MEASUREMENT USING A QUARTZ CRYSTAL ANALYZER
MURAMATSU, H
YE, XJ
ATAKA, T
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1993, 347 (1-2): : 247 - 255
[13] Orientation of an Optically Trapped Non-Spherical Micro-Particle using Iterative Learning Control
Edlund, Connor
Shrivastava, Rachit
Salapaka, Murti, V
2022 AMERICAN CONTROL CONFERENCE, ACC, 2022, : 4764 - 4771
[14] Effect of Trapped Charges on Local Potential Measurement of Carbon Nanotubes Using Frequency-Modulation Kelvin-Probe Force Microscopy
Ito, Masanao
Hosokawa, Yoshihiro
Nishi, Ryuji
Miyato, Yuji
Kobayashi, Kei
Matsushige, Kazumi
Yamada, Hirofumi
E-JOURNAL OF SURFACE SCIENCE AND NANOTECHNOLOGY, 2011, 9 : 210 - 214
[15] Local pH monitoring of small cluster of cells using a fiber-optic dual-core micro-probe
Chen, Sisi
Yang, Qingbo
Xiao, Hai
Shi, Honglan
Ma, Yinfa
SENSORS AND ACTUATORS B-CHEMICAL, 2017, 241 : 398 - 405
[16] Investigation of local orientation and stress analysis of PZT-based materials using micro-probe polarized Raman spectroscopy
Deluca, Marco
Sakashita, Tatsuo
Galassi, Carmen
Pezzotti, Giuseppe
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2006, 26 (12) : 2337 - 2344
[17] Probing Nanoparticle-Cell Interaction Using Micro-Raman Spectroscopy: Silver and Gold Nanoparticle-Induced Stress Effects on Optically Trapped Live Red Blood Cells
Barkur, Surekha
Lukose, Jijo
Chidangil, Santhosh
ACS OMEGA, 2020, 5 (03): : 1439 - 1447

← 1 2 →