A proteomics-based methodology to investigate the protein corona effect for targeted drug delivery

被引：16

作者：

Pozzi, D. ^{[1
]}

Caracciolo, G. ^{[1
]}

Capriotti, A. L. ^{[2
]}

Cavaliere, C. ^{[2
]}

Piovesana, S. ^{[2
]}

Colapicchioni, V. ^{[3
]}

Palchetti, S. ^{[4
]}

Riccioli, A. ^{[4
]}

Lagana, A. ^{[2
]}

机构：

[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] Ist Italiano Tecnol, Ctr Life Nanosci Sapienza, I-00161 Rome, Italy

[4] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthopaed, Sect Histol & Med Embryol, I-00161 Rome, Italy

来源：

MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 11期

关键词：

NANOPARTICLE UPTAKE; LIPOSOMES; MEMBRANE; SURFACE;

D O I：

10.1039/c4mb00292j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we introduce a proteomics methodology based on nanoliquid-chromatography tandem mass spectrometry (nanoLC/MS-MS) to investigate the "protein corona effect for targeted drug delivery", an innovative strategy, which exploits the "protein corona" that forms around nanoparticles in a physiological environment to target cells.

引用

页码：2815 / 2819

页数：5

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