A proteomics-based methodology to investigate the protein corona effect for targeted drug delivery

被引：16
|
作者：
Pozzi, D. [1 ]
Caracciolo, G. [1 ]
Capriotti, A. L. [2 ]
Cavaliere, C. [2 ]
Piovesana, S. [2 ]
Colapicchioni, V. [3 ]
Palchetti, S. [4 ]
Riccioli, A. [4 ]
Lagana, A. [2 ]
机构：
[1] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy
[3] Ist Italiano Tecnol, Ctr Life Nanosci Sapienza, I-00161 Rome, Italy
[4] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthopaed, Sect Histol & Med Embryol, I-00161 Rome, Italy
来源：
MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 11期
关键词：
NANOPARTICLE UPTAKE; LIPOSOMES; MEMBRANE; SURFACE;
D O I：
10.1039/c4mb00292j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we introduce a proteomics methodology based on nanoliquid-chromatography tandem mass spectrometry (nanoLC/MS-MS) to investigate the "protein corona effect for targeted drug delivery", an innovative strategy, which exploits the "protein corona" that forms around nanoparticles in a physiological environment to target cells.
引用
收藏
页码：2815 / 2819
页数：5
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