An enantioselective formal total synthesis of (-)-TAN1251A

被引：22

作者：

Auty, JMA

Churcher, I

Hayes, CJ

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

SYNLETT | 2004年 / 08期

关键词：

total synthesis; alkaloid; carbene insertion; asymmetric synthesis; spiro compounds;

D O I：

10.1055/s-2004-829092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective total synthesis of the muscarinic inhibitor (-)-TAN1251A has been achieved. An alkylidene 1,5-CH insertion reaction was used as a keystep to produce a [5,5]-spirocyclic intermediate, which was transformed into the [6,5]-spirocyclic core of the natural product via an oxidative cleavage/aldol condensation sequence. The synthesis of the natural product was then completed using standard procedures.

引用

页码：1443 / 1445

页数：3

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