Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives

被引：7
|
作者：
Dascalu, Anca-Elena [1 ,2 ,3 ,4 ]
Ghinet, Alina [1 ,2 ,4 ]
Billamboz, Muriel [1 ,2 ]
Lipka, Emmanuelle [1 ,3 ]
机构：
[1] Univ Lille, INSERM, U995, LIRIC, F-59000 Lille, France
[2] Ecole Hautes Etud Ingn HEI, Lab Pharmacochim, 13 Rue Toul, F-59046 Lille, France
[3] UFR Pharm, Lab Chim Analyt, BP 83, F-59006 Lille, France
[4] Alexandru Ioan Cuza Univ, Fac Chem, Bd Carol I 11, Iasi 700506, Romania
来源：
JOURNAL OF PHARMACEUTICAL ANALYSIS | 2019年 / 9卷 / 04期
关键词：
Antibacterial compounds; Chirality; Enantiomers; Flow-rate; Particle size; CELLULOSE; AMYLOSE; ENANTIOSEPARATION; QUANTIFICATION; THROUGHPUT; DESIGN;
D O I：
10.1016/j.jpha.2019.03.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 degrees C and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%. We have observed that 15% of methanol gave the best results for most of the compounds. For all the derivatives, the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5. (C) 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
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页码：248 / 253
页数：6
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