An efficient method for the preparation of nitriles via the dehydration of aldoximes with phthalic anhydride

被引：28
|
作者：
Wang, EC [1 ]
Huang, KS
Chen, HM
Wu, CC
Lin, GJ
机构：
[1] Kaohsiung Med Univ, Fac Med & Appl Chem, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Inst Pharmaceut Sci, Kaohsiung 807, Taiwan
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2004年 / 51卷 / 03期
关键词：
aldoximes; plithalic anhydride; nitriles;
D O I：
10.1002/jccs.200400093
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new and highly efficient method for the conversion of aldoximes to nitriles was established. By fusing with phthalic anhydride, aldoximes were efficiently and smoothly converted into nitriles, in high yields (over 85%) and in a short time (within 5 minutes). The mixture of phthalic anhydride, a cyclic anhydride, and aldoximes in fusing state set up an ideal transition state for a selective [3.3]-sigmatropic rearrangement of the acylated aldoximes to nitriles.
引用
收藏
页码：619 / 627
页数：9
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