Immune evasion of the CD1d/NKT cell axis

被引:14
|
作者
Brutkiewicz, Randy R. [1 ]
Yunes-Medina, Laura [1 ]
Liu, Jianyun [1 ]
机构
[1] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
基金
美国国家卫生研究院;
关键词
KILLER T-CELLS; CD1D-MEDIATED ANTIGEN PRESENTATION; IMMUNODEFICIENCY-VIRUS-INFECTION; NKT CELLS; DENDRITIC CELLS; MURINE CYTOMEGALOVIRUS; LISTERIA-MONOCYTOGENES; ADAPTIVE IMMUNITY; MULTIPLE-MYELOMA; CYTOPLASMIC TAIL;
D O I
10.1016/j.coi.2018.04.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity. In contrast, here, we discuss the ways that viruses, bacteria and tumor cells can evade the CD1d/NKT cell axis. As a result, these disease states have a better chance to establish a foothold and potentially cause problems for the subsequent adaptive immune response, as the host tries to rid itself of infections or tumors.
引用
收藏
页码:87 / 92
页数:6
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