The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia

被引:33
|
作者
Dodell-Feder, David [1 ]
DeLisi, Lynn E. [2 ,3 ]
Hooker, Christine I. [1 ]
机构
[1] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
[2] Boston VA Med Ctr, Brockton, MA 02301 USA
[3] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA
基金
美国国家卫生研究院;
关键词
Schizophrenia Familial high-risk; Default mode network; Functional connectivity; Social functioning; Social cognition; RESTING-STATE; 1ST-DEGREE RELATIVES; PSYCHIATRIC-DISORDERS; SYNAPTIC PLASTICITY; PREFRONTAL CORTEX; MIND IMPAIRMENTS; BIPOLAR DISORDER; ADOLESCENTS; ANHEDONIA; PEOPLE;
D O I
10.1016/j.schres.2014.03.031
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Unaffected first-degree relatives of individuals with schizophrenia (i.e., those at familial high-risk [FHR]), demonstrate social dysfunction qualitatively similar though less severe than that of their affected relatives. These social difficulties may be the consequence of genetically conferred disruption to aspects of the default mode network (DMN), such as the dMPFC subsystem, which overlaps with the network of brain regions recruited during social cognitive processes. In the present study, we investigate this possibility, testing DMN connectivity and its relationship to social functioning in FHR using resting-state fMRI. Twenty FHR individuals and 17 controls underwent fMRI during a resting-state scan. Hypothesis-driven functional connectivity analyses examined ROI-to-ROI correlations between the DMN's hubs, and regions of the dMPFC subsystem and MTL subsystem. Connectivity values were examined in relationship to a measure of social functioning and empathy/perspective-taking. Results demonstrate that FHR exhibit reduced connectivity specifically within the dMPFC subsystem of the DMN. Certain ROI-to-ROI correlations predicted aspects of social functioning and empathy/perspective-taking across all participants. Together, the data indicate that disruption to the dMPFC subsystem of the DMN may be associated with familial risk for schizophrenia, and that these intrinsic connections may carry measurable consequences for social functioning. (C) 2014 Elsevier B. V. All rights reserved.
引用
收藏
页码:87 / 95
页数:9
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