Increased Default Mode Network Connectivity in Individuals at High Familial Risk for Depression

被引:84
|
作者
Posner, Jonathan [1 ,2 ]
Cha, Jiook [1 ,2 ]
Wang, Zhishun [1 ,2 ]
Talati, Ardesheer [1 ,2 ]
Warner, Virginia [1 ,2 ]
Gerber, Andrew [1 ,2 ]
Peterson, Bradley S. [3 ,4 ]
Weissman, Myrna [1 ,2 ]
机构
[1] Columbia Univ, Coll Phys & Surg, Dept Psychiat, Unit 74,1051 Riverside Dr, New York, NY 10032 USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Univ So Calif, Childrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA USA
[4] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA
关键词
STATE FUNCTIONAL CONNECTIVITY; MEDICATION-NAIVE CHILDREN; MULTIVARIATE-ANALYSIS; PREFRONTAL CORTEX; COGNITIVE CONTROL; MAJOR DEPRESSION; CINGULATE CORTEX; HUMAN BRAIN; TASK; MRI;
D O I
10.1038/npp.2015.342
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Research into the pathophysiology of major depressive disorder (MDD) has focused largely on individuals already affected by MDD. Studies have thus been limited in their ability to disentangle effects that arise as a result of MDD from precursors of the disorder. By studying individuals at high familial risk for MDD, we aimed to identify potential biomarkers indexing risk for developing MDD, a critical step toward advancing prevention and early intervention. Using resting-state functional connectivity MRI (rs-fcMRl) and diffusion MRI (tractography), we examined connectivity within the default mode network (DMN) and between the DMN and the central executive network (CEN) in III individuals, aged 11-60 years, at high and low familial risk for depression. Study participants were part of a three generation longitudinal, cohort study of familial depression. Based on rs-fcMRl, individuals at high vs low familial risk for depression showed increased DMN connectivity, as well as decreased DMN-CEN-negative connectivity. These findings remained significant after excluding individuals with a current or lifetime history of depression. Diffusion MRI measures based on tractography supported the findings of decreased DMN-CEN-negative connectivity. Path analyses indicated that decreased DMN-CEN-negative connectivity mediated a relationship between familial risk and a neuropsychological measure of impulsivity. Our findings suggest that DMN and DMN-CEN connectivity differ in those at high vs low risk for depression and thus suggest potential biomarkers for identifying individuals at risk for developing MDD.
引用
收藏
页码:1759 / 1767
页数:9
相关论文
共 50 条
  • [1] Increased Default Mode Network Connectivity in Individuals at High Familial Risk for Depression
    Jonathan Posner
    Jiook Cha
    Zhishun Wang
    Ardesheer Talati
    Virginia Warner
    Andrew Gerber
    Bradley S Peterson
    Myrna Weissman
    [J]. Neuropsychopharmacology, 2016, 41 : 1759 - 1767
  • [2] INCREASED DEFAULT MODE NETWORK CONNECTIVITY IN INDIVIDUALS AT HIGH FAMILIAL RISK FOR DEPRESSION
    Posner, Jonathan
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2016, 55 (10): : S306 - S306
  • [3] Default Mode Network Connectivity and Familial Risk for Depression
    Posner, Jonathan
    Wang, Zhishun
    Talati, Ardesheer
    Warner, Virginia
    Weissman, Myrna
    [J]. NEUROPSYCHOPHARMACOLOGY, 2014, 39 : S490 - S491
  • [4] The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia
    Dodell-Feder, David
    DeLisi, Lynn E.
    Hooker, Christine I.
    [J]. SCHIZOPHRENIA RESEARCH, 2014, 156 (01) : 87 - 95
  • [5] The default mode network and rumination in individuals at risk for depression
    Chou, Tina
    Deckersbach, Thilo
    Dougherty, Darin D.
    Hooley, Jill M.
    [J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2023, 18 (01)
  • [6] Default Network Functional Connectivity and Social Functioning in Individuals at Familial High-Risk for Schizophrenia
    Dodell-Feder, David
    Osborne, K. Juston
    Guty, Erin
    DeLisi, Lynn E.
    Hooker, Christine I.
    [J]. BIOLOGICAL PSYCHIATRY, 2014, 75 (09) : 58S - 58S
  • [7] Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression
    Svob, Connie
    Wang, Zhishun
    Weissman, Myrna M.
    Wickramaratne, Priya
    Posner, Jonathan
    [J]. NEUROSCIENCE LETTERS, 2016, 634 : 94 - 97
  • [8] Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals
    Hwang, J. W.
    Xin, S. C.
    Ou, Y. M.
    Zhang, W. Y.
    Liang, Y. L.
    Chen, J.
    Yang, X. Q.
    Chen, X. Y.
    Guo, T. W.
    Yang, X. J.
    Ma, W. H.
    Li, J.
    Zhao, B. C.
    Tu, Y.
    Kong, J.
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2016, 76 : 111 - 120
  • [9] Default Mode Network Connectivity as a Function of Familial and Environmental Risk for Psychotic Disorder
    Peeters, Sanne C. T.
    van de Ven, Vincent
    Gronenschild, Ed H. B. M.
    Patel, Ameera X.
    Habets, Petra
    Goebel, Rainer
    van Os, Jim
    Marcelis, Machteld
    [J]. PLOS ONE, 2015, 10 (03):
  • [10] Brain Default Mode Network Connectivity and Familial Risk of Major Mood Disorders
    Murage, Daniel
    Drobinin, Vladislav
    Nazarova, Anna
    Howes-Vallis, Emily
    Helmick, Carl
    Schmidt, Matthias
    Newman, Aaron
    Bowen, Christopher
    Uher, Rudolf
    [J]. BIOLOGICAL PSYCHIATRY, 2023, 93 (09) : S95 - S95