Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

被引：2

作者：

Khidkhan, Kraisiri ^{[1
]}

Mizukawa, Hazuki ^{[1
,2
]}

Ikenaka, Yoshinori ^{[1
,3
]}

Nakayama, Shouta M. M. ^{[1
]}

Nomiyama, Kei ^{[4
]}

Yokoyama, Nozomu ^{[1
]}

Ichii, Osamu ^{[1
,5
]}

Takiguchi, Mitsuyoshi ^{[1
]}

Tanabe, Shinsuke ^{[4
]}

Ishizuka, Mayumi ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Vet Med, Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan

[2] Ehime Univ, Grad Sch Agr, Dept Sci & Technol Biol Resources & Environm, 3-5-7 Tarumi, Matsuyama, Ehime 7908566, Japan

[3] North West Univ, Unit Environm Sci & Management, Water Res Grp, ZA-2531 Potchefstroom, South Africa

[4] Ehime Univ, Ctr Marine Environm Studies CMES, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan

[5] Hokkaido Univ, Fac Agr, Lab Agrobiomed Sci, Kita 9,Nishi 9, Sapporo, Hokkaido 0608589, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2020年 / 82卷 / 07期

基金：

日本学术振兴会;

关键词：

BDE-209; cat; chronic exposure; cytochrome P450; mRNA expression; DIPHENYL ETHER; ENDOCRINE DISRUPTION; OXIDATIVE-METABOLISM; TISSUE DISTRIBUTION; FLAME RETARDANTS; HOUSE-DUST; BIOTRANSFORMATION; PBDES; LIVER; RESIDENTS;

D O I：

10.1292/jvms.20-0140

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1-CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers ( PBDEs) in cat.

引用

页码：978 / 982

页数：5

共 50 条

[41] Altered Hepatic Cytochrome P450: Implication on Hepatic Lipid Dysregulation in Intrauterine Growth Restricted Offspring
Wolfe, Diana S.
Han, Guang
Ross, Michael G.
Desai, Mina
REPRODUCTIVE SCIENCES, 2010, 17 (03) : 103A - 104A
[42] HIGH DIETARY FAT FEEDING DURING PREGNANT ALTERS HEPATIC CYTOCHROME P450 EXPRESSION OF PROGENY IN MICE TAKEHIRO OKANIWA HEPATIC CYTOCHROME P450 EXPRESSION OF PROGENY IN MICE
Okaniwa, T.
Imahori, Y.
Saruta, K.
Toda, T.
Ishii, M.
Ikarashi, N.
Ochiai, W.
Sugiyama, K.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2011, 109 : 92 - 92
[43] Uptake and depuration kinetics of lead (Pb) and biomarker responses in the earthworm Eisenia fetida after simultaneous exposure to decabromodiphenyl ether (BDE209)
Zhang, Wei
Liu, Kou
Li, Jing
Chen, Lin
Lin, Kuangfei
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2015, 113 : 45 - 51
[44] Effects of bicyclol on the activity and expression of cytochrome P450 after hepatic warm ischemia/reperfusion in rats
Yao, Xiao-Min
Wang, Bao-Lian
Yu, Hong-Yan
Li, Yan
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2011, 13 (07) : 634 - 644
[45] Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats
Sang Yoon Lee
Soo Jin Oh
Kang Uk Yun
Hwan Mook Kim
Bong-Hee Kim
Kiho Lee
Sang Kyum Kim
Archives of Toxicology, 2012, 86 : 75 - 85
[46] Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats
Lee, Sang Yoon
Oh, Soo Jin
Yun, Kang Uk
Kim, Hwan Mook
Kim, Bong-Hee
Lee, Kiho
Kim, Sang Kyum
ARCHIVES OF TOXICOLOGY, 2012, 86 (01) : 75 - 85
[47] Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
Sadler, Natalie C.
Nandhikonda, Premchendar
Webb-Robertson, Bobbie-Jo
Ansong, Charles
Anderson, Lindsey N.
Smith, Jordan N.
Corley, Richard A.
Wright, Aaron T.
DRUG METABOLISM AND DISPOSITION, 2016, 44 (07) : 984 - 991
[48] Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice
Wang, Dujun
Wang, Kai
Sui, Danjuan
Ouyang, Zhen
Xu, Haiyu
Wei, Yuan
CHEMICO-BIOLOGICAL INTERACTIONS, 2017, 268 : 47 - 52
[49] A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy
Tateishi, T
Nakura, H
Asoh, M
Watanabe, M
Tanaka, M
Kumai, T
Takashima, S
Imaoka, S
Funae, Y
Yabusaki, Y
Kamataki, T
Kobayashi, S
LIFE SCIENCES, 1997, 61 (26) : 2567 - 2574
[50] Acute effect of DDT on hepatic cytochrome P450 expression in ovariectomized rats
Sierra-Santoyo, A.
Castorena-Torres, F.
Vazquez, P.
Bermudez de Leon, M.
Lopez-Gonzalez, L.
TOXICOLOGY LETTERS, 2011, 205 : S190 - S190

← 1 2 3 4 5 →