Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

被引：2

作者：

Khidkhan, Kraisiri ^{[1
]}

Mizukawa, Hazuki ^{[1
,2
]}

Ikenaka, Yoshinori ^{[1
,3
]}

Nakayama, Shouta M. M. ^{[1
]}

Nomiyama, Kei ^{[4
]}

Yokoyama, Nozomu ^{[1
]}

Ichii, Osamu ^{[1
,5
]}

Takiguchi, Mitsuyoshi ^{[1
]}

Tanabe, Shinsuke ^{[4
]}

Ishizuka, Mayumi ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Vet Med, Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan

[2] Ehime Univ, Grad Sch Agr, Dept Sci & Technol Biol Resources & Environm, 3-5-7 Tarumi, Matsuyama, Ehime 7908566, Japan

[3] North West Univ, Unit Environm Sci & Management, Water Res Grp, ZA-2531 Potchefstroom, South Africa

[4] Ehime Univ, Ctr Marine Environm Studies CMES, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan

[5] Hokkaido Univ, Fac Agr, Lab Agrobiomed Sci, Kita 9,Nishi 9, Sapporo, Hokkaido 0608589, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2020年 / 82卷 / 07期

基金：

日本学术振兴会;

关键词：

BDE-209; cat; chronic exposure; cytochrome P450; mRNA expression; DIPHENYL ETHER; ENDOCRINE DISRUPTION; OXIDATIVE-METABOLISM; TISSUE DISTRIBUTION; FLAME RETARDANTS; HOUSE-DUST; BIOTRANSFORMATION; PBDES; LIVER; RESIDENTS;

D O I：

10.1292/jvms.20-0140

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1-CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers ( PBDEs) in cat.

引用

页码：978 / 982

页数：5

共 50 条

[31] Decabrominated diphenyl ether (BDE-209) and/or BDE-47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis
Song, Jie
Li, Zhi-hua
He, Yu-Tian
Liu, Chuan-Xin
Sun, Bin
Zhang, Chun-Fang
Zeng, Jie
Du, Pei-Li
Zhang, Hui-li
Yu, Yan-hong
Chen, Dun-Jin
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2014, 33 : 8 - 14
[32] Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: Detoxification by hepatic cytochrome p450 is more important than metabolic activation
Arit, V. M.
Stiborova, M.
Henderson, C. J.
Thieniann, M.
Frei, E.
Singh, R.
da Costa, G. G.
Schmitz, O. J.
Farmer, P. B.
Wolf, C. R.
Phillips, D. H.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2007, 375 : 73 - 73
[33] Toxicity responses of bacterial community as a biological indicator after repeated exposure to lead (Pb) in the presence of decabromodiphenyl ether (BDE209)
Bo Liu
Rong Zhang
Xiaoqian Xia
Wei Zhang
Mengwen Gao
Qiang Lu
Kuangfei Lin
Environmental Science and Pollution Research, 2018, 25 : 36278 - 36286
[34] Toxicity responses of bacterial community as a biological indicator after repeated exposure to lead (Pb) in the presence of decabromodiphenyl ether (BDE209)
Liu, Bo
Zhang, Rong
Xia, Xiaoqian
Zhang, Wei
Gao, Mengwen
Lu, Qiang
Lin, Kuangfei
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2018, 25 (36) : 36278 - 36286
[35] Hepatic expression of cytochrome P450 in Zucker diabetic fatty rats
Park, So Young
Kim, Chung Hyeon
Lee, Ji Yoon
Jeon, Jang Su
Kim, Min Ju
Chae, Song Hee
Kim, Hyoung Chin
Oh, Soo Jin
Kim, Sang Kyum
FOOD AND CHEMICAL TOXICOLOGY, 2016, 96 : 244 - 253
[36] Expression of cytochrome P450 isoforms in rat hepatic stellate cells
Yamada, T
Imaoka, S
Kawada, N
Seki, S
Kuroki, T
Kobayashi, K
Monna, T
Funae, Y
LIFE SCIENCES, 1997, 61 (02) : 171 - 179
[37] Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice
Piekos, Stephanie C.
Chen, Liming
Wang, Pengcheng
Shi, Jian
Yaqoob, Sharon
Zhu, Hao-Jie
Ma, Xiaochao
Zhong, Xiao-bo
DRUG METABOLISM AND DISPOSITION, 2018, 46 (08) : 1241 - 1250
[38] Exposure to benzo(a) pyrene in the hepatic cytochrome P450 oxidoreductase (POR) null mouse:: detoxification by hepatic cytochrome P450 is more important than metabolic activation
Arlt, Volker M.
Stiborova, Marie
Henderson, Colin J.
Thiemann, Markus
Frei, Eva
Aimova, Dagmar
Singh, Rajinder
da Costa, Goncalo Gamboa
Schmitz, Oliver J.
Farmer, Peter B.
Wolf, C. Roland
Phillips, David H.
MUTAGENESIS, 2007, 22 (06) : 439 - 439
[39] Absorption, tissue distribution, metabolism, and elimination of decabrominated diphenyl ether (BDE-209) in rats after multi-dose oral exposure
Mi, Xiu-Bo
Bao, Lian-Jun
Wu, Chen-Chou
Wong, Charles S.
Zeng, Eddy Y.
CHEMOSPHERE, 2017, 186 : 749 - 756
[40] INTERACTION OF BENZANTHRONE WITH CYTOCHROME P450 - ALTERED PATTERNS OF HEPATIC XENOBIOTIC METABOLISM IN RATS
DAS, M
GARG, K
JOSHI, A
SINGH, GB
KHANNA, SK
JOURNAL OF BIOCHEMICAL TOXICOLOGY, 1991, 6 (01): : 37 - 44

← 1 2 3 4 5 →