Expression of tumor necrosis factor-α in IgM+ B-cells from bovine leukemia virus-infected lymphocytotic sheep

被引：3

作者：

Usui, Tatsufumi ^{[1
]}

Konnai, Satoru ^{[1
]}

Ohashi, Kazuhiko ^{[1
]}

Onuma, Misao ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Infect Dis Lab, Sapporo, Hokkaido 0600818, Japan

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2006年 / 112卷 / 3-4期

基金：

日本学术振兴会;

关键词：

BLV; TNF-alpha; B-cell; IMMUNE-RESPONSES; TNF-ALPHA; PROLIFERATION; RECEPTORS;

D O I：

10.1016/j.vetimm.2006.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF)-cL is thought to be one of the cytokines that account for bovine leukemia virus (BLV)-induced B-cell lymphoproliferative disorder, however, information on TNF-alpha expression in B-cells is limited. In this study, the expression of TNF-alpha in IgM(+) B-cells from BLV-infected sheep with or without lymphocytosis was determined. Freshly isolated IgM(+) B-cells from three sheep with lymphocytosis constitutively transcribed TNF-alpha mRNA. Although TNF-alpha mRNA expression in IgM(+) B-cells was transiently up-regulated after cell culture, TNF-alpha mRNA expression was markedly higher in lymphocytotic sheep when compared to that of non-lymphocytotic sheep or uninfected sheep. Expression of membranebound TNF-alpha on IgM(+) B-cells was also augmented in lymphocytotic sheep. TNF-alpha expression in lymphocytotic sheep may support the proliferation of B-cells. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：296 / 301

页数：6

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