Expression of tumor necrosis factor-α in IgM+ B-cells from bovine leukemia virus-infected lymphocytotic sheep

被引：3
|
作者：
Usui, Tatsufumi [1 ]
Konnai, Satoru [1 ]
Ohashi, Kazuhiko [1 ]
Onuma, Misao [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Infect Dis Lab, Sapporo, Hokkaido 0600818, Japan
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2006年 / 112卷 / 3-4期
基金：
日本学术振兴会;
关键词：
BLV; TNF-alpha; B-cell; IMMUNE-RESPONSES; TNF-ALPHA; PROLIFERATION; RECEPTORS;
D O I：
10.1016/j.vetimm.2006.03.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumor necrosis factor (TNF)-cL is thought to be one of the cytokines that account for bovine leukemia virus (BLV)-induced B-cell lymphoproliferative disorder, however, information on TNF-alpha expression in B-cells is limited. In this study, the expression of TNF-alpha in IgM(+) B-cells from BLV-infected sheep with or without lymphocytosis was determined. Freshly isolated IgM(+) B-cells from three sheep with lymphocytosis constitutively transcribed TNF-alpha mRNA. Although TNF-alpha mRNA expression in IgM(+) B-cells was transiently up-regulated after cell culture, TNF-alpha mRNA expression was markedly higher in lymphocytotic sheep when compared to that of non-lymphocytotic sheep or uninfected sheep. Expression of membranebound TNF-alpha on IgM(+) B-cells was also augmented in lymphocytotic sheep. TNF-alpha expression in lymphocytotic sheep may support the proliferation of B-cells. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：296 / 301
页数：6
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