Hepatitis C virus infection in intravenous drug users

被引：17

作者：

Harder, J

Walter, E

Riecken, B

Ihling, C

Bauer, TM

机构：

[1] Univ Freiburg, Med Klin, Innere Med Abt 2, Dept Pathol, D-79106 Freiburg, Germany

[2] Univ Freiburg, Univ Hosp, Dept Med Gastroenterol Hepatol & Infect Dis 2, Freiburg, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 08期

关键词：

drug users; hepatitis C; liver function tests; liver histology;

D O I：

10.1111/j.1469-0691.2004.00934.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Intravenous drug use (IVDU) remains a major means of hepatitis C virus (HCV) transmission. In this study, 101 drug users were studied prospectively after cessation of IVDU. Of these, 75.8% were anti-HCV positive, and 71.4% had elevated levels of alanine aminotransferase. These levels decreased significantly within 1 month of IVDU cessation (p 0.02). Liver biopsies showed minimal or mild fibrosis in 32 (71%) of 45 subjects, and severe fibrosis in two (4.4%) subjects. Anti-HCV-positive intravenous drug users in this study presented with mild liver disease and variable stages of disease progression. Biochemical disease activity might be affected by IVDU.

引用

页码：768 / 770

页数：3

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