Novel synthesis of a highly sterically hindered C2-symmetric chiral pyridine derivative

被引：8
|
作者：
Kotsuki, H
Sakai, H
Jun, JG
Shiro, M
机构：
[1] Kochi Univ, Fac Sci, Dept Mat Sci, Kochi 7808520, Japan
[2] Hallym Univ, Dept Chem, Chunchon 200702, South Korea
[3] Rigaku Corp, Tokyo 1968666, Japan
来源：
HETEROCYCLES | 2000年 / 52卷 / 02期
关键词：
D O I：
10.3987/COM-99-S64
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly sterically hindered C-2-symmetric chiral pyridine derivative (3) was synthesized from 1,5-diketone (2) by the action of NH4OAc/Cu(OAc)(2) in refluxing propionic acid. The pK(a) of 3 was determined to be 6.26 and the structure was characterized by X-Ray crystallographic analysis of its triflic acid salt.
引用
收藏
页码：661 / 666
页数：6
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