Chronic pain: role of pharmacogenetics in antidepressant treatment failure

被引：0

作者：

Rodieux, F. ^{[1
]}

Berney, P. ^{[1
]}

Desmeules, J. ^{[1
]}

Besson, M. ^{[1
]}

机构：

[1] Hop Univ Genevois, Unite Psychopharmacol Clin, Serv Pharmacol & Toxicol Clin, Dept Anesthesiol Pharmacol & Soins Intensifs, CH-1211 Geneva 14, Switzerland

来源：

DOULEUR ET ANALGESIE | 2013年 / 26卷 / 04期

关键词：

Antidepressant; Pain; Resistance; Pharmacogenetics; CATECHOL-O-METHYLTRANSFERASE; SEROTONIN TRANSPORTER GENE; MAJOR DEPRESSIVE DISORDER; POLYMORPHISM 5-HTTLPR ASSOCIATION; HUMAN CYTOCHROME-P450 ENZYMES; MONOAMINE-OXIDASE-A; PROMOTER POLYMORPHISM; VAL158MET POLYMORPHISM; TREATMENT RESPONSE; CLINICAL-RESPONSE;

D O I：

10.1007/s11724-013-0355-7

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Part of the interindividual variability in antidepressants response is explained by genetic polymorphisms of the enzymes involved in the pharmacokinetics or pharmacodynamics of these drugs. The results are nevertheless mostly conflicting. Recommendations for antidepressants dosage based on the CYPP450 activity have been published. However, they have not been tested prospectively.

引用

页码：218 / 225

页数：8

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