Hepcidin levels in diabetes mellitus and polycystic ovary syndrome

被引:63
|
作者
Sam, A. H. [1 ]
Busbridge, M. [2 ]
Amin, A. [1 ]
Webber, L. [3 ]
White, D. [3 ]
Franks, S. [3 ]
Martin, N. M. [1 ]
Sleeth, M. [1 ]
Ismail, N. A. [1 ]
Daud, N. Mat [1 ]
Papamargaritis, D. [1 ]
Le Roux, C. W. [1 ]
Chapman, R. S.
Frost, G. [1 ]
Bloom, S. R. [1 ]
Murphy, K. G. [1 ]
机构
[1] Hammersmith Hosp, Imperial Coll London, Sect Invest Med, London, England
[2] Imperial Coll Healthcare NHS Trust, Dept Clin Biochem, London, England
[3] Hammersmith Hosp, Imperial Coll London, Inst Reprod & Dev Biol, London, England
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
PEPTIDE HEPCIDIN; IRON-METABOLISM; SERUM HEPCIDIN; INSULIN; GENE;
D O I
10.1111/dme.12262
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimIncreased body iron is associated with insulin resistance. Hepcidin is the key hormone that negatively regulates iron homeostasis. We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load. MethodsSerum concentrations of the active form of hepcidin (hepcidin-25) and hepcidin:ferritin ratio were evaluated in participants with Type2 diabetes (n=33, control subjects matched for age, gender and BMI, n=33) and participants with polycystic ovary syndrome (n=27, control subjects matched for age and BMI, n=16). To investigate whether any changes observed were associated with insulin resistance rather than insulin deficiency or hyperglycaemia per se, the same measurements were made in participants with Type1 diabetes (n=28, control subjects matched for age, gender and BMI, n=30). Finally, the relationship between homeostasis model assessment of insulin resistance and serum hepcidin:ferritin ratio was explored in overweight or obese participants without diabetes (n=16). ResultsParticipants with Type2 diabetes had significantly lower hepcidin and hepcidin:ferritin ratio than control subjects (P<0.05 and P<0.01, respectively). Participants with polycystic ovary syndrome had a significantly lower hepcidin:ferritin ratio than control subjects (P<0.05). There was no significant difference in hepcidin or hepcidin:ferritin ratio between participants with Type1 diabetes and control subjects (P=0.88 and P=0.94). Serum hepcidin:ferritin ratio inversely correlated with homeostasis model assessment of insulin resistance (r=-0.59, P<0.05). ConclusionInsulin resistance, but not insulin deficiency or hyperglycaemia per se, is associated with inadequate hepcidin levels. Reduced hepcidin concentrations may cause increased body iron stores in insulin-resistant states.
引用
收藏
页码:1495 / 1499
页数:5
相关论文
共 50 条
  • [41] Adiponectin levels in women with polycystic ovary syndrome
    Orio, F
    Palomba, S
    Cascella, T
    Milan, G
    Mioni, R
    Pagano, C
    Zullo, F
    Colao, A
    Lombardi, G
    Vettor, R
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06): : 2619 - 2623
  • [42] Increased homocysteine levels in polycystic ovary syndrome
    de la Calle, Maria
    Gallardo, Teresa
    Diestro, M. Dolores
    Hernanz, Angel
    Perez, Elia
    Fernandez-Miranda, Consuelo
    MEDICINA CLINICA, 2007, 129 (08): : 292 - 294
  • [43] Plasma homocysteine levels in polycystic ovary syndrome
    Atanasova, A.
    Popovska, S.
    Dimitrov, G. L.
    ATHEROSCLEROSIS SUPPLEMENTS, 2006, 7 (03) : 273 - 273
  • [44] Paraoxonase levels in women with polycystic ovary syndrome
    Fenkci, Ibrahim V.
    Serteser, Mustafa
    Fenkci, Semin
    Kose, Songul
    JOURNAL OF REPRODUCTIVE MEDICINE, 2007, 52 (10) : 879 - 883
  • [45] Ovarian morphology and prevalence of polycystic ovary syndrome in Japanese women with type 1 diabetes mellitus
    Miyoshi, Arina
    Nagai, So
    Takeda, Masamitsu
    Kondo, Takuma
    Nomoto, Hiroshi
    Kameda, Hiraku
    Hirai, Amiko
    Cho, Kyuyong
    Kimachi, Kimihiko
    Shimizu, Chikara
    Atsumi, Tatsuya
    Miyoshi, Hideaki
    JOURNAL OF DIABETES INVESTIGATION, 2013, 4 (03) : 326 - 329
  • [46] Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome
    Xiao, Qing
    Cui, Yong-Yi
    Lu, Jine
    Zhang, Guo-Zheng
    Zeng, Fang-Ling
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2016, 2016
  • [47] Prevalence, pathogenesis and management of prediabetes and type 2 diabetes mellitus in patients with polycystic ovary syndrome
    Sofia Lazaridou
    Konstantinos Dinas
    Konstantinos Tziomalos
    Hormones, 2017, 16 : 373 - 380
  • [48] Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome
    Sir-Petermann, T
    Angel, B
    Maliqueo, M
    Carvajal, F
    Santos, JL
    Pérez-Bravo, F
    DIABETOLOGIA, 2002, 45 (07) : 959 - 964
  • [49] The role of glycated hemoglobin in the diagnosis of prediabetes and diabetes mellitus in young women with polycystic ovary syndrome
    Melo, Raissa Holanda
    Pontes, Ana Gabriela
    Delmanto, Lucia Regina Marques Gomes
    Bueloni-Dias, Flavia Neves
    Vespoli, Heloisa De Luca
    Nahas, Eliana Aguiar Petri
    CLINICAL ENDOCRINOLOGY, 2024, 100 (02) : 124 - 131
  • [50] Risk prediction of gestational diabetes mellitus in women with polycystic ovary syndrome based on a nomogram model
    Ouyang, Peilin
    Duan, Siqi
    You, Yiping
    Jia, Xiaozhou
    Yang, Liqin
    BMC PREGNANCY AND CHILDBIRTH, 2023, 23 (01)