Hepcidin levels in diabetes mellitus and polycystic ovary syndrome

被引:63
|
作者
Sam, A. H. [1 ]
Busbridge, M. [2 ]
Amin, A. [1 ]
Webber, L. [3 ]
White, D. [3 ]
Franks, S. [3 ]
Martin, N. M. [1 ]
Sleeth, M. [1 ]
Ismail, N. A. [1 ]
Daud, N. Mat [1 ]
Papamargaritis, D. [1 ]
Le Roux, C. W. [1 ]
Chapman, R. S.
Frost, G. [1 ]
Bloom, S. R. [1 ]
Murphy, K. G. [1 ]
机构
[1] Hammersmith Hosp, Imperial Coll London, Sect Invest Med, London, England
[2] Imperial Coll Healthcare NHS Trust, Dept Clin Biochem, London, England
[3] Hammersmith Hosp, Imperial Coll London, Inst Reprod & Dev Biol, London, England
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
PEPTIDE HEPCIDIN; IRON-METABOLISM; SERUM HEPCIDIN; INSULIN; GENE;
D O I
10.1111/dme.12262
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimIncreased body iron is associated with insulin resistance. Hepcidin is the key hormone that negatively regulates iron homeostasis. We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load. MethodsSerum concentrations of the active form of hepcidin (hepcidin-25) and hepcidin:ferritin ratio were evaluated in participants with Type2 diabetes (n=33, control subjects matched for age, gender and BMI, n=33) and participants with polycystic ovary syndrome (n=27, control subjects matched for age and BMI, n=16). To investigate whether any changes observed were associated with insulin resistance rather than insulin deficiency or hyperglycaemia per se, the same measurements were made in participants with Type1 diabetes (n=28, control subjects matched for age, gender and BMI, n=30). Finally, the relationship between homeostasis model assessment of insulin resistance and serum hepcidin:ferritin ratio was explored in overweight or obese participants without diabetes (n=16). ResultsParticipants with Type2 diabetes had significantly lower hepcidin and hepcidin:ferritin ratio than control subjects (P<0.05 and P<0.01, respectively). Participants with polycystic ovary syndrome had a significantly lower hepcidin:ferritin ratio than control subjects (P<0.05). There was no significant difference in hepcidin or hepcidin:ferritin ratio between participants with Type1 diabetes and control subjects (P=0.88 and P=0.94). Serum hepcidin:ferritin ratio inversely correlated with homeostasis model assessment of insulin resistance (r=-0.59, P<0.05). ConclusionInsulin resistance, but not insulin deficiency or hyperglycaemia per se, is associated with inadequate hepcidin levels. Reduced hepcidin concentrations may cause increased body iron stores in insulin-resistant states.
引用
收藏
页码:1495 / 1499
页数:5
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