Feedback-error learning (FEL) neural network was developed for control of a powered trans-femoral prosthesis. Nonlinearities and time-variations of the dynamics of the plant, in addition to redundancy and dynamic uncertainty during the double support phase of walking, makes conventional control methods very difficult to use. Rule-based control, which uses a knowledge base determined by machine learning and finite automata method is limited since it does not respond well to perturbations and environmental changes. FEL can be regarded as a hybrid control, because it combines nonparametric identification with parametric modeling and control. This paper presents simulation of a powered trans-femoral prosthesis controlled by a FEL neural network. Results suggest that FEL can be used to identify inverse dynamics of an arbitrary trans-femoral prosthesis during simple single joint movements (e.g., sinusoidal oscillations). The identified inverse dynamics then allows the tracking of an arbitrary trajectory such as a desired walking pattern within a multijoint structure, Simulation shows that the identified controller responds correctly when the Leg motion is exposed to a perturbation such as a frequent change of the ground reaction force or the hip joint torque generated by the user. FEL eliminates the need for precise, tedious, and complex identification of model parameters.