Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with copper(II) and cobalt(II): Preparation, crystal structure and urease inhibitory activity

被引：19

作者：

Habala, L. ^{[1
]}

Roller, A. ^{[2
]}

Matuska, M. ^{[1
]}

Valentova, J. ^{[1
]}

Rompel, A. ^{[3
]}

Devinsky, F. ^{[1
]}

机构：

[1] Comenius Univ, Fac Pharm, SK-83232 Bratislava, Slovakia

[2] Univ Vienna, Fac Chem, Inst Inorgan Chem, A-1090 Vienna, Austria

[3] Univ Vienna, Fac Chem, Dept Biophys Chem, A-1090 Vienna, Austria

来源：

INORGANICA CHIMICA ACTA | 2014年 / 421卷

关键词：

Copper(II) complexes; Cobalt(II) complexes; Aminopolycarboxylate ligands; Crystal structure; Urease inhibition; BASE METAL-COMPLEXES; BACTERIAL UREASES; BENZIMIDAZOLE; IONS;

D O I：

10.1016/j.ica.2014.06.035

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Novel copper(II) and cobalt(II) complexes of the N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid were prepared and their X-ray crystal structures were determined. Both complexes are hexacoordinate and exhibit a distorted octahedral geometry. The urease inhibitory activity of the complexes was measured (alongside with the free ligand and acetohydroxamic acid as reference substance). The copper(II) complex exhibits a pronounced inhibitory activity against urease (with IC50 value of 35 +/- 2 mu M being significantly lower than that of the free ligand and of acetohydroxamic acid co-assayed as reference), whereas the cobalt(II) complex shows only negligible activity. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：423 / 426

页数：4

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