Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with copper(II) and cobalt(II): Preparation, crystal structure and urease inhibitory activity

被引：19
|
作者：
Habala, L. [1 ]
Roller, A. [2 ]
Matuska, M. [1 ]
Valentova, J. [1 ]
Rompel, A. [3 ]
Devinsky, F. [1 ]
机构：
[1] Comenius Univ, Fac Pharm, SK-83232 Bratislava, Slovakia
[2] Univ Vienna, Fac Chem, Inst Inorgan Chem, A-1090 Vienna, Austria
[3] Univ Vienna, Fac Chem, Dept Biophys Chem, A-1090 Vienna, Austria
来源：
INORGANICA CHIMICA ACTA | 2014年 / 421卷
关键词：
Copper(II) complexes; Cobalt(II) complexes; Aminopolycarboxylate ligands; Crystal structure; Urease inhibition; BASE METAL-COMPLEXES; BACTERIAL UREASES; BENZIMIDAZOLE; IONS;
D O I：
10.1016/j.ica.2014.06.035
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Novel copper(II) and cobalt(II) complexes of the N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid were prepared and their X-ray crystal structures were determined. Both complexes are hexacoordinate and exhibit a distorted octahedral geometry. The urease inhibitory activity of the complexes was measured (alongside with the free ligand and acetohydroxamic acid as reference substance). The copper(II) complex exhibits a pronounced inhibitory activity against urease (with IC50 value of 35 +/- 2 mu M being significantly lower than that of the free ligand and of acetohydroxamic acid co-assayed as reference), whereas the cobalt(II) complex shows only negligible activity. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：423 / 426
页数：4
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