APPLICATION OF SUPERCRITICAL CARBON DIOXIDE TO ENHANCE DISSOLUTION RATE OF BICALUTAMIDE

被引：0

作者：

Antosik, Agata ^{[1
]}

Witkowski, Stefan ^{[2
]}

Woyna-Orlewicz, Krzysztof ^{[1
]}

Talik, Przemyslaw ^{[3
]}

Szafraniec, Joanna ^{[1
]}

Wawrzuta, Beata ^{[1
]}

Jachowicz, Renata ^{[1
]}

机构：

[1] Jagiellonian Univ, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, Med 9 St, PL-30688 Krakow, Poland

[2] Jagiellonian Univ, Fac Chem, Ingardena 3 St, PL-30060 Krakow, Poland

[3] Jagiellonian Univ, Fac Pharm, Dept Inorgan & Analyt Chem, Med 9 St, PL-30688 Krakow, Poland

来源：

ACTA POLONIAE PHARMACEUTICA | 2017年 / 74卷 / 04期

关键词：

bicalutamide; supercritical carbon dioxide; solid dispersion; dissolution; Poloxamer; 407; WATER-SOLUBLE DRUG; SOLID DISPERSION; PARTICLE DESIGN; MICRONIZATION; POLYMORPHISM;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bicalutamide solid dispersions were prepared by supercritical fluid method using carbon dioxide as a solvent. Approximately 8-told dissolution improvement was noticed for system prepared with supercritical carbon dioxide containing Poloxamer 407 as a carrier, when compared to physical mixture. The system was characterized using scanning electron microscopy. X-ray powder diffraction and differential scanning calorimetry. We found that applying the supercritical fluid treatment led to significant decrease in bicalutamide crystals size and their partial amorphization. The studies confirmed that use of supercritical fluid technology might be efficient for dissolution rate enhancement of poorly water soluble drugs.

引用

页码：1231 / 1238

页数：8

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