APPLICATION OF SUPERCRITICAL CARBON DIOXIDE TO ENHANCE DISSOLUTION RATE OF BICALUTAMIDE

Bicalutamide solid dispersions were prepared by supercritical fluid method using carbon dioxide as a solvent. Approximately 8-told dissolution improvement was noticed for system prepared with supercritical carbon dioxide containing Poloxamer 407 as a carrier, when compared to physical mixture. The system was characterized using scanning electron microscopy. X-ray powder diffraction and differential scanning calorimetry. We found that applying the supercritical fluid treatment led to significant decrease in bicalutamide crystals size and their partial amorphization. The studies confirmed that use of supercritical fluid technology might be efficient for dissolution rate enhancement of poorly water soluble drugs.