A non-cryogenic method for the preparation of 2-(indolyl) borates, silanes, and silanols

被引：54
|
作者：
Vazquez, E [1 ]
Davies, IW [1 ]
Payack, JF [1 ]
机构：
[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 21期
关键词：
D O I：
10.1021/jo026087j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Indolyl borates are prepared via addition of LDA to a mixture of N-Boc-indole and triisopropyl borate at 0-5 degreesC. Following acidic hydrolysis, the boronic acids are isolated by crystallization in good to excellent yield (73-99%). The method is quite general, tolerating a wide range of functional groups, and also provides access to 2-silyl derivatives (80-91%).
引用
收藏
页码：7551 / 7552
页数：2
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