A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use

被引：9
|
作者：
Schmaljohann, J [1 ]
Gündisch, D
Minnerop, M
Joe, A
Bucerius, J
Dittmar, C
Jessen, F
Guhlke, S
Wüllner, U
机构：
[1] Univ Bonn, Dept Neurol, D-53105 Bonn, Germany
[2] Univ Bonn, Dept Nucl Med, D-5300 Bonn, Germany
[3] Univ Bonn, Dept Pharmaceut Chem, D-5300 Bonn, Germany
[4] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany
[5] MC Pharma GmbH, Bonn, Germany
来源：
APPLIED RADIATION AND ISOTOPES | 2005年 / 63卷 / 04期
关键词：
nicotinic acetylcholine receptor; fluor-18; 2-F-18-A85380; PET;
D O I：
10.1016/j.apradiso.2005.05.040
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
2-[F-18]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of alpha(4)beta(2) nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[F-18]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[F-18]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：433 / 435
页数：3
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